Skip to content

Health & Pregnancy

Font Size

Multiple Miscarriages Linked to Gene

WebMD Health News

July 30, 2001-- Having a baby seems like an impossible dream to women who have recurrent miscarriages. For about half of these women, doctors are able to identify a specific problem causing the miscarriages, such as infections, hormonal imbalances, or immune problems. And for some of these, there are possible treatments. For the other half, however, experts have found no explanation.

That is, until now.

Austrian researchers may have uncovered why some of these remaining women miscarry: It's genetic. Given this new finding, reported in the August issue of Human Reproduction, infertility experts can look for new treatments for this devastating problem.

"Usually miscarriage happens in about 10-20% of [women trying to have a baby], but when someone has three or more miscarriages, their chances of having another miscarriage are very high, ... from 30-50% or 60%," infertility expert Matan Yemini, MD, tells WebMD. He is co-director of Diamond Institute for Infertility and Menopause in Millburn, N.J., and was not involved in the study.

Study author Clemens Tempfer, MD, and colleagues from the department of obstetrics and gynecology at the University of Vienna School of Medicine in Austria, have linked recurrent, unexplained miscarriage to the specific gene variation, called NOS3. Women who carry this variation tend to produce less nitric oxide. In the uterus, nitric oxide causes blood vessels to expand, thereby improving blood flow to the uterus and to the growing fetus.

The researchers compared 105 who had recurrent miscarriages to 91 postmenopausal women who had given birth at least twice and never had a miscarriage. They found that the women who had miscarried were more likely to carry the NOS3 gene variation.

Interestingly, drugs that help improve blood flow to the uterus or decrease the likelihood of blood clotting are already used to treat recurrent miscarriage. This research helps explain why this approach works.

According to expert Andrew Toledo, MD, who also reviewed the study for WebMD, "most of us that do work in repetitive miscarriage have always felt that in unexplained couples, ... there must be a molecular, genetic component to this." Toledo, a partner at Reproductive Biology Associates in Atlanta, specializes in reproductive endocrinology, infertility, and recurrent miscarriage.

Pregnancy Week-By-Week Newsletter

Delivered right to your inbox, get pictures and facts on
what to expect each week of your pregnancy.

Today on WebMD

hand circling date on calendar
Track your most fertile days.
woman looking at ultrasound
Week-by-week pregnancy guide.
Pretty pregnant woman timing contaction pains
The signs to watch out for.
pregnant woman in hospital
Are there ways to do it naturally?
slideshow fetal development
pregnancy first trimester warning signs
What Causes Bipolar
Woman trying on dress in store
pregnant woman
Close up on eyes of baby breastfeeding
healthtool pregnancy calendar
eddleman prepare your body pregnancy

WebMD Special Sections