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Asthma Drug Soothes RSV-Related Cough

Singulair May Help Babies With Common Lung Condition Breathe Easier

WebMD Health News

Feb. 14, 2003 -- A drug used to treat asthma may also calm the wheezing and coughing associated with a lung condition common among babies known as respiratory syncytial virus (RSV). New research shows Singulair (montelukast) eased symptoms and helped infants recover from some of the lingering lung and other breathing problems that frequently follow RSV.

According to the American Academy of Pediatrics (AAP), RSV is the most common cause of lower respiratory tract infections in children and is the leading cause of hospitalization for babies under 1 year old. More than 125,000 infants with RSV are hospitalized each year and about 2% die.

Babies become infected with RSV by the time they reach age 2. In most healthy infants, the virus causes only cold-like symptoms such as cough, fever, and runny nose. But in certain, high-risk infants, such as those born prematurely or with lung disease, RSV can cause serious complications and require hospitalization.

Researchers say many infants who are hospitalized with RSV continue to suffer from wheeze and other asthma-like symptoms long after they are discharged.

"We don't know if these symptoms are actually due to the RSV, asthma, or something else in these children," researcher Hans Bisgaard, MD, professor of pediatrics at Copenhagen University Hospital tells WebMD.

Some studies have suggested that babies who suffer from post-RSV wheeze and cough are more likely to develop asthma later in childhood, but that link isn't clear.

But researchers do know that during serious RSV cases infants release substances known as leukotrienes in the lungs, which are thought to contribute to the dangerous inflammation that occurs.

"This drug [Singulair] blocks leukotrienes," says Bisgaard. "And since we know leukotrienes are one of the mediators of post-RSV wheeze, we decided to target them. Just like taking an antihistamine for hay fever blocks the mediator that causes those symptoms."

Researchers compared the effects of daily treatment with a 5 mg chewable tablet of Singulair with placebo in 116 infants who were hospitalized for RSV. The treatment began within seven days after the start of RSV symptoms and lasted for 28 days.

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