Are Antidepressants Safe During Pregnancy?
Report Offers Guidelines for Treating Depression in Pregnant Women
WebMD News Archive
Aug. 21, 2009 -- Women who take antidepressants face a difficult choice when
they become pregnant, and for many the risks vs. benefits of continuing
treatment are not clear, a joint report from the American Psychiatric
Association and the American College of Obstetricians and Gynecologists
The report confirms that there are far more questions than answers about the
dangers antidepressants pose to the babies born to women who take them.
It also presents guidelines to help doctors and patients identify who should
and should not consider stopping drug treatment.
Pregnant women who experience psychotic episodes, have bipolar disorder, or
who are suicidal or have a history of suicide attempts should not be taken off
antidepressants, the report concludes.
"We know that untreated depression poses real risks to babies. That is not
conjecture," Yale University School of Medicine ob-gyn Charles Lockwood, MD,
tells WebMD. "We know much less about the risks associated with antidepressant
use. It is clear that more study is needed."
According to one study, the rate of antidepressant use during pregnancy more
than doubled between 1999 and 2003. The study found that in 2003, one in eight
women took an antidepressant at some point during her pregnancy.
Greater use of selective serotonin reuptake inhibitor (SSRI) antidepressants
like Prozac, Paxil, and Zoloft were largely responsible for the increase.
These drugs were generally considered safe for pregnant women at the time,
but safety concerns soon emerged, especially regarding Paxil.
Separate studies from Sweden and the U.S. suggested an increased risk for
congenital heart defects in babies born to women who took Paxil during
The reports led the FDA to issue an advisory in December 2005 warning about
the potential risk based on early results of two studies.
But the joint panel found the evidence linking Paxil use during pregnancy to
heart problems in newborns to be inconclusive.
Lockwood tells WebMD that if the risk is real, it is probably not limited to
"It is very likely to be a class effect and not just this one drug," he