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    Diabetes, Hypertension, Obesity Linked to Autism

    Study Suggests Women With These Conditions May Have Greater Risk of Having an Autistic Child
    WebMD Health News
    Reviewed by Laura J. Martin, MD

    May 11, 2011 (San Diego) -- Women who have diabetes, high blood pressure, or are obese before pregnancy are more likely to have a child with autism, according to new research.

    "For mothers with at least one of these conditions, there was a 60% increased risk for autism in the offspring," says Irva Hertz-Picciotto, PhD, an autism researcher at the University of California, Davis MIND Institute.

    She presented her findings at the International Meeting for Autism Research in San Diego.

    Autism and autism spectrum disorders (ASD) are a group of developmental disorders that can cause significant social, communication, and behavioral problems. About one in 110 U.S. children has ASD, according to CDC estimates. Recent research from South Korea has suggested the number may be much higher.

    Seeking Clues on Development of Autism

    For the study, Hertz-Picciotto and her colleagues evaluated 1,001 children. Of that group, 508 had autism or ASD, 178 had developmental delays, and 315 were typically developing children.

    All were enrolled in the ongoing CHARGE study (CHildhood Autism Risks from Genetics and the Environment).

    Researchers retrieved information on type 2 diabetes, obesity before the pregnancy, and high blood pressure by doing telephone interviews with the mothers and looking at medical records.

    After adjusting for factors such as a mother's education, the researchers found that mothers of children with ASD were about 60% more likely to have one of the three conditions.

    The mothers of children who were delayed developmentally were about 150% more likely to be obese before pregnancy, have diabetes, or have high blood pressure.

    "This again is further evidence there is potentially metabolic disruption and some sort of inflammatory pathway [linking the conditions]," Hertz-Picciotto says.

    The researchers decided to explore the link due to recent statistics showing an increase in diabetes, obesity, and high blood pressure and the parallel rise in autism rates.

    Second Opinion

    The new research finding a link between diabetes and autism reflects findings of some earlier studies, according to Geraldine Dawson, PhD, chief science officer for Autism Speaks, an advocacy group and a sponsor of the meeting.

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