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Health & Pregnancy

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Hormone Treatment May Drastically Reduce Preterm Births

Huge Drop Seen in Women Given Progesterone

Progesterone to Prevent Preterm Birth

Progesterone is a crucial hormone for maintaining pregnancy. If progesterone declines, it can lead to shortening of the cervix. This can raise the risk of preterm delivery.

Romero and his team looked at the results of five previously published studies. Each compared vaginal progesterone to a placebo. Vaginal progesterone comes in several forms, such as a capsule, gel, or suppository.

The studies included 775 women and 827 infants.

The 42% reduced risk was for birth before 33 weeks. The progesterone also reduced the risk of birth before 28, 32, and 35 weeks.

"Early preterm birth is less common, but those babies have many complications," Romero tells WebMD.

Progesterone treatment also reduced the risk of breathing problems by about 52% and the need for mechanical ventilation by 34%. Fewer babies whose mothers got the progesterone had to be admitted to neonatal intensive care units.

The progesterone also helped those women who had had a previous preterm birth and a short cervix, the researchers found.

FDA to Consider Progesterone Treatment

If an ultrasound taken at 19 to 24 weeks shows a shortened cervix, the researchers say, doctors should consider recommending a 90-milligram-a-day dose of vaginal progesterone starting at about 20 weeks.

On Jan. 20, 2012, the FDA will consider an application jointly submitted by Columbia Laboratories and Watson Pharmaceuticals to approve a vaginal progesterone gel for prevention of preterm labor. The FDA is expected to decide by late February 2012, says Charlie Mayr, a spokesperson for Watson Pharmaceuticals.

Mayr couldn't disclose costs of the new gel, which may be called Prochieve.

One of the study’s researchers, John O'Brien, MD, was involved in vaginal progesterone studies sponsored by Columbia Laboratories. He also serves on advisory boards and is a consultant for Watson Pharmaceuticals. He is listed on the patent for the use of progesterone to prevent preterm birth.

Vaginal Progesterone Treatment a Game Changer?

The new findings ''will cause a change in practice," says Jill Rabin, MD, chief of ambulatory care, obstetrics, and gynecology, and head of urogynecology at the Long Island Jewish Medical Center in New Hyde Park, N.Y.

She reviewed the findings but was not involved in the research.

She calls the reduction in preterm births significant.

The recommendation to obtain routine ultrasounds ''doesn't add much in the way of cost," Rabin tells WebMD. The ultrasounds are routinely given to assess the pregnancy.

Women should know the status of their cervix when pregnant, Rabin says. "During prenatal care, it's important to discuss the length of the cervix with your physician. If a doctor doesn't discuss it, ask: 'Does my cervix look OK?'"

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