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Antidepressants in Pregnancy & Lung Risk in Babies

But, overall risk of 'persistent pulmonary hypertension' remains low, study finds

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That means that between 286 and 351 women would need to be treated with an SSRI in late pregnancy to result in an average of one additional case of persistent pulmonary hypertension, according to the study.

One difficulty for the researchers was pinning down the precise meaning of "late" pregnancy, as studies in the review had varying definitions. Late pregnancy could mean anytime during or after the 20th week, or it could mean during the third trimester, among other time frames.

Although the study found an increased risk of the lung problem, it wasn't designed to prove that the medications directly caused the problem. Grigoriadis said it's not clear exactly how SSRIs could cause persistent pulmonary hypertension.

She said that women shouldn't stop taking their medications, instead they should talk to their doctors if they have concerns.

"Decisions on treatment need to be personalized. Women need to make informed decisions by taking in all the risks of depression and its treatments. Psychosocial treatments [such as counseling] are appropriate for some women, depending on how severe the depression is, and how quickly [a woman] might respond to treatment," Grigoriadis said.

For her part, Frieder said, "It's good to see someone put all of these studies together in a uniform way. It makes me feel more comfortable about giving these medications. The risk is low, but it needs to be put into context with a woman's history. Treatment choices need to be individualized."

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