Methotrexate side effects are more likely to cause problems
when treatment lasts for many months, which is common in cancer and rheumatoid
arthritis treatment. But side effects do occur when methotrexate is given
to end an
The most common side
effects of methotrexate treatment for ectopic pregnancy are nausea and
indigestion. Side effects vary from woman to woman. And some women do not
experience any side effects. If you are treated with methotrexate, you will be followed
closely by your doctor.
The suggestions below may
help you manage methotrexate side effects. Tell your doctor about
any symptoms you have during your treatment.
Eat small meals more frequently instead of three
large meals daily.
Ask your doctor about
using an antinausea (antiemetic) medicine, such as prochlorperazine or
ondansetron (Zofran) to prevent or reduce nausea.
Rest as much
Try to eliminate strong odors from your
Do not use nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and aspirin, which can
increase the risk of stomach irritation.
slowly, especially when moving from a sitting to a standing
Allow others to assist you when you walk.
For a sore mouth and throat (stomatitis)
Avoid coffee, spicy and salty foods, and citrus
fruits. These foods can further aggravate your sore mouth.
foods such as ice cream, custards, or gelatin.
Rinse your mouth
every 2 hours with a lukewarm saltwater solution. Mix
1 tsp (5 g)
of table salt in
8 fl oz (240 mL) of lukewarm
water. Do not swallow the saltwater solution, because it can upset your
Eat mild foods, such as rice, dry toast or
crackers, bananas, and applesauce. Avoid spicy foods, other fruits, alcohol,
coffee, and dairy products.
This information is produced and provided by the National
Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National
Institute via the Internet web site at http://
.gov or call 1-800-4-CANCER.
WebMD Medical Reference from Healthwise
November 14, 2014
This information is not intended to replace the advice of a doctor.
Healthwise disclaims any liability for the decisions you make based on this