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Anger Linked to Heart Disease

Anger, Hostility, and Depression Tied to Inflammation, Heart Disease Risk

Understanding Depression and Heart Disease

Researchers say the findings may be the first step in understanding the complex relationship between psychological factors such as depression and heart disease.

"It's noteworthy that people are at last looking for mechanisms to explain the pretty well-established link between depression and heart disease," says Sylvia Wassertheil-Smoller, PhD, professor of epidemiology and population health at Albert Einstein College of Medicine of Yeshiva University in New York.

But she says it's still unclear, which direction the relationship flows, whether depression increases inflammation or if inflammation is a part of a syndrome that includes depression and other underlying processes.

"Nevertheless it's a biochemical link between depression and heart disease because we know that CRP identifies people at future risk of heart disease," Wassertheil-Smoller tells WebMD. "It is a very interesting link that needs to be pursued."

Lawson Wulsin, MD, associate professor of psychiatry and family medicine at the University of Cincinnati says this study adds to a growing body of research on the interplay between the entire inflammatory process, depression, and heart disease.

"Both depression and C-reactive protein are in the running as candidates for the next major risk factor for coronary heart disease, says Wulsin. "To show that they are linked at least in time is a step toward the process of showing that they may be linked by cause and effect or that they may be operating on the same pathway that later increases the risk for heart disease."

Researchers say the next step will be to conduct long-term studies to see if the elevated CRP levels associated with depression, anger, and hostility are associated with higher rates of heart disease over time.

Once the relationship between inflammation and psychological factors is clearly established, researchers say they can begin looking at new targets for heart disease prevention and treatment by either by targeting the psychological symptoms or the inflammation itself.

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