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Stress May Cause Fat Around the Midsection in Lean Women

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Sept. 22, 2000 (New York) -- They may look thin, but even some slender women have problems with fat. A new study finds that lean women who are stressed-out may be more likely to have "spare tires" around their midsections -- which increases their risk of certain diseases, including heart disease and diabetes.

"Our findings support the idea that greater life stress and stress reactivity can contribute to central fat, especially among lean women," says study author Elissa Epel, PhD. "For lean women, central fat may indicate an underlying sensitivity to stress rather than being in part a result of obesity." Epel, who was a research scientist at Yale University in New Haven, Conn., when the study was conducted, is now with the Health Psychology Program at the University of California, San Francisco.

The study, which appears in the journal Psychosomatic Medicine, looked at 59 women. Half had a high waist-to-hip ratio, indicating an apple-shaped body with fat accumulating around the waist; the other half had a low waist-to-hip ratio, with more fat around the hips.

Overall, the women with high waist-to-hip ratios were more vulnerable to the effects of stress, as measured by standard tests over a four-day period. But overweight women with high waist-to-hip ratios seemed to adapt to the tests by the second and third days, while lean women with high waist-to-hip ratios continued to secrete higher levels of the stress hormone cortisol in response to the tests.

The findings confirm some earlier work by Pamela M. Peeke, MD, MPH, a former senior scientist at the National Institutes of Health in Bethesda, Md., and an associate clinical professor of medicine at the University of Maryland School of Medicine in Baltimore.

Calling fat in the central part of the body "toxic weight," Peeke tells WebMD that "it is the only fat on the human body that is associated with death and dying from heart disease, hypertension [high blood pressure], diabetes, stroke, and some forms of cancer."

Central fat tends to be highly sensitive to the effects of circulating stress hormones like cortisol, and prolonged exposure to cortisol causes an accumulation of "toxic weight," says Peeke, the author of Fight Fat After 40.

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