Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Collagen Injections

Collagen injections give your skin a plumper, smoother appearance. Although collagen is the best known filler, there are many other substances doctors can use to plump up your skin, including fat from your own body and synthetic materials. Below you will find a detailed explanation of how collagen works, followed by a list of other injectable fillers your doctor may recommend.


To understand collagen, you should first understand your skin.

Skin consists of three layers: the epidermis, dermis, and subcutaneous tissue (hypodermis). The upper-most layer, known as the epidermis, controls the loss of water from cells and tissue.

Without this protective barrier, the body would quickly dehydrate.

Just below the epidermis lies the second layer, the dermis. The dermis, although it contains blood vessels, nerves, and hair follicles, is primarily made up of a protein called "collagen." This protein forms a network of fibers that provides a framework for the growth of cells and blood vessels. Because it is the primary component of the dermis, collagen acts as the support structure for the skin. The hypodermis is a layer of fat and connective tissue that contains larger blood vessels and nerves. It also hosts sweat glands, fat, and collagen cells. The hypodermis is responsible for conserving your body's heat and protecting your vital inner organs.

Why Do Lines Appear on Skin?

In young skin, the collagen framework is intact and the skin remains moisturized and elastic. It's resilient to the many facial expressions we adopt, as well as everyday environmental exposure. But, over time, the support structure weakens and the skin loses its elasticity. The skin begins to lose its tone as the collagen support wears down. Every time you smile, frown, or squint, you put stress on the collagen in your skin. The effect of these facial expressions is cumulative and facial lines begin to appear.

URAC: Accredited Health Web Site TRUSTe online privacy certification HONcode Seal AdChoices