Poly-L lactic Acid (Sculptra) Fillers
When injected under the skin, poly-L lactic acid (PLLA) stimulates skin cells to make collagen. Poly-L lactic acid is nontoxic and has been widely used in suture material for years.
PLLA is FDA-approved for cosmetic treatment of certain skin conditions in people with HIV. It is often legally used "off-label" to treat wrinkles in otherwise healthy people. It's considered "semi-permanent," meaning results can last for months to years.
Calcium Hydroxyapatite (Radiesse) Fillers
In 2006, the FDA approved calcium hydroxyapatite for cosmetic injection. This cosmetic filler is made of the minerals that give bone its strength and texture. These minerals are ground into tiny particles and suspended in water solution, which is injected under the skin.
In the trial that led to its approval, calcium hydroxyapatite worked significantly better and lasted longer than collagen injections to reduce severe wrinkles.
Polymethyl methacrylate (PMMA) Fillers
Polymethyl methacrylate is a permanent cosmetic filler. Before the FDA approved it for that use, PMMA was already being used as a cement for bone surgery.
That's right -- we said "cement." Polymethyl methacrylate doesn't break down. So, unlike biological products, PMMA produces permanent cosmetic results.