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    Cosmetics Industry Says Most Not Used Now -- Safety of Another 115 Under Review

    22 Hair Dye Chemicals Banned in Europe

    Newer Studies Fail to Show Link

    The study that prompted the review, published in 2001 in the International Journal of Cancer, compared the hair dye histories of 897 women with bladder cancerbladder cancer with those of an equal number of women without the disease.

    Women who used permanent hair dyes regularly (at least once a month) for 15 years or more were found to be three times as likely as women who didn't dye their hair to develop bladder cancer.

    But both Bailey and Schellauf point to more recent studies that do not support a link between hair dye use and bladder cancer.

    These include an analysis of 10 studies regarding hair dye use and bladdercancer published in the Journal of the American Medical Association in 2005 and a study from Spain involving roughly 300 women, reported in this month's European Journal of Cancer.

    The European Commission is expected to report on the safety of the 115 chemicals it is evaluating by December 2007.

    In a statement issued late Friday, FDA officials suggested they will be watching the European regulatory group's actions.

    The complete list of chemicals included in the ban:

    Chemical name
    6-Methoxy-2,3-Pyridinediamine and its HCl salt
    4,5-Diamino-1-Methylpyrazole and its HCl salt
    4,5-Diamino-1-((4-Chlorophenyl)Methyl)-1H-Pyrazole Sulfate
    4-Methoxytoluene-2,5-Diamine and its HCl salt
    5-Amino-4-Fluoro-2-Methylphenol Sulfate
    N,N-Dimethyl-2,6-Pyridinediamine and its HCl salt
    N-(2-Methoxyethyl)-p-phenylenediamine and its HCl salt
    2,4-Diamino-5-methylphenetol and its HCl salt
    3,4-Diaminobenzoic acid
    2-Aminomethyl-p-aminophenol and its HCl salt
    Solvent Red 1 (CI 12150)
    Acid Orange 24 (CI 20170)
    Acid Red 73 (CI 27290)

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