Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started
My Medicine

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Study Shows Topical Gel May Help Reduce Wrinkles Around the Eyes

WebMD Health News

Needle-Free Wrinkle Treatment Works Like Botox

Sept. 21, 2011 -- Wrinkle relief for those whose fear of needles outweighs their vanity may be on the horizon.

A topical gel containing botulinum toxin type A -- the same toxin as that used in injected Botox -- helped reduce moderate to severe crow's feet wrinkling around the eyes, according to two preliminary studies.

"The gel contains botulinum toxin type A and a peptide carrier, which is what helps the botulinum toxin gel penetrate the skin," says researcher Michael Kane, MD, a New York City plastic surgeon.

In two studies including 270 patients with mild to severe crow's feet, ''we found good effectiveness," he says. At the four-week mark, 89% of the patients in one study had some improvement in wrinkles around the eyes, he says.

He is due to present the results at Plastic Surgery 11, the annual meeting of the American Society of Plastic Surgeons, in Denver on Saturday.

The research was a phase II study. Phase III research is needed before seeking FDA approval. The research was funded by Revance Therapeutics, which makes the gel.

Wrinkle Relief Without Needles

Kane applied the topical gel around the eye area to reduce the crow's feet wrinkles. It is meant to reduce wrinkles by penetrating the skin and relaxing the underlying muscles.

"There is an applicator used to apply the gel to the area," Kane says. "The gel sits on the area for 30 minutes. Then it is wiped off and the patient walks out."

In one study, he assigned 90 patients to get either the new gel treatment or a placebo gel treatment.

After four weeks, both the patient and the doctor rated the results. They used a five-point scale.

Nearly 89% of the patients who got the active gel had at least a one-point or more improvement, compared to nearly 28% who got the inactive placebo. About 45% of those treated with the active gel had at least a two-point improvement or more on the five-point scale, Kane says. None in the comparison group had a two-point or more improvement.

In a second study, 180 patients were assigned to one of four groups:

  • Treatment with the botulinum toxin gel in the carrier system that helps it penetrate
  • The carrier alone
  • The gel alone
  • Placebo gel
URAC: Accredited Health Web Site TRUSTe online privacy certification HONcode Seal AdChoices