Monoamine Oxidase Inhibitors (MAOIs) for Bipolar Disorder
Monoamine oxidase inhibitors treat depression by preventing the breakdown of serotonin, dopamine, and norepinephrine in the brain, increasing their availability. These medications are not used often because of their potential for drug interactions that can lead to problems with blood pressure as well as the need to avoid foods that contain the amino acid tyramine.
Bipolar disorder is a serious diagnosis that affects more than 10 million Americans. Unlike depression, bipolar disorder is equally common in men and women. The onset of the condition typically occurs in the early 20s, but (although rare) the first symptoms can appear in early childhood or late in life.
Although some people may have only one episode, bipolar disorder is a lifelong condition that usually involves recurrent episodes. It's usually marked by episodes of mania or hypomania (low-grade...
Among these, Parnate has been the most extensively studied specifically in bipolar depression, leading in one randomized trial to improvement in over 80% of subjects. Like other classes of antidepressants, the MAOIs take several weeks to begin working. Your doctor may also prescribe a sedative to help relieve anxiety, agitation, or sleep problems while the antidepressant begins to work. You will also need to monitor what foods you eat to avoid side effects.
MAOI Side Effects
Eating certain smoked, fermented, or pickled foods, drinking certain beverages, or taking certain medications can cause severe, sudden high blood pressure in combination with MAOIs. People taking these antidepressants must follow a special diet.
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National Institute of Mental Health: "Step-BD Womens Studies."
Massachusetts General Hospital Bipolar Clinic & Research Program.
MedicineNet: "Bipolar Disorder (Mania)."
WebMD Medical Reference: "Effects of Untreated Depression."
American Psychiatric Association: "Practice Guideline for the Treatment of Patients With Bipolar Disorder."