Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Bipolar Disorder Health Center

Font Size

Monoamine Oxidase Inhibitors (MAOIs) for Bipolar Disorder

Monoamine oxidase inhibitors are an extremely potent class of antidepressants that treat depression by preventing the breakdown of serotonin, dopamine, and norepinephrine in the brain, increasing their availability. These medications are not used often because of their potential for drug interactions that can lead to problems with blood pressure as well as the need to avoid foods that contain the amino acid tyramine. Generally, like most antidepressants, MAOIs should be used for bipolar depression only in combination with a mood stabilizer such as lithium or valproate, to minimize the risk of inducing mania.

Antidepressants in this class of drugs that can be used for bipolar depression include:

Recommended Related to Bipolar Disorder

Psychotherapy for Bipolar Disorder

Psychotherapy, or "talk" therapy, is an important part of treatment for bipolar disorder. During therapy, you can discuss feelings, thoughts, and behaviors that cause you problems. Talk therapy can help you understand and hopefully master any problems that hurt your ability to function well in your life and career. It also helps you stay on your medication. It can help you maintain a positive self-image. The types of psychotherapy used to treat bipolar disorder include: Behavioral...

Read the Psychotherapy for Bipolar Disorder article > >

Among these, Parnate has been the most extensively studied specifically in bipolar depression, leading in one randomized trial to improvement in over 80% of subjects. Like other classes of antidepressants, the MAOIs take several weeks to begin working. Your doctor may also prescribe a sedative to help relieve anxiety, agitation, or sleep problems while the antidepressant begins to work. You will also need to monitor what foods you eat to avoid side effects.

MAOI Side Effects

Eating certain smoked, fermented, or pickled foods, drinking certain beverages, or taking certain medications can cause severe, sudden high blood pressure in combination with MAOIs. People taking these antidepressants must follow a special diet.

Common side effects of MAOIs may include:

WebMD Medical Reference

Reviewed by Joseph Goldberg, MD on July 31, 2014

Today on WebMD

lunar eclipse
Signs of mania and depression.
Pills on blank prescription paper
Learn about this popular bipolar disorder medication.
serious looking young woman
Assess your symptoms.
teen girl in bad mood
How is each one different?
Feeling Ups and Downs
Bipolar or Schizo
Foods to Avoid
Man being scolded by his shadow
lunar eclipse
depressed man
young women not speaking
man talking with therapist