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Tricyclic Antidepressants for Bipolar Disorder

Older tricyclic antidepressants used for treating bipolar disorder may be more likely to trigger a manic episode or rapid cycling than other depression drugs. They also tend to have more side effects than newer generation antidepressants, and can be especially dangerous in overdose. However, they are occasionally still used when other antidepressants are not effective, or when certain other conditions (such as migraine or neuropathic pain disorders) are also present. Like all antidepressants, experts recommend against taking a tricyclic medication without a mood stabilizer (such as lithium or divalproex) to minimize the chance of inducing mania symptoms.

Tricyclic antidepressants include:

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Tips for Managing Bipolar Disorder at Work

If you have bipolar disorder, no one needs to tell you how challenging this mental illness can be. You are among millions of American adults who may also find that the mood episodes of bipolar disorder can be very disruptive at work. Take heart. There are many steps you can take to find meaningful work and develop successful relationships on -- and off -- the job.

Read the Tips for Managing Bipolar Disorder at Work article > >

Tricyclic antidepressants work by increasing levels of the mood chemicals serotonin and norepinephrine in the brain. However, because they may sometimes increase the risk of mania or rapid cycling -- as well as heart problems if you take heart medication -- these drugs are less often recommended for bipolar disorder.

WebMD Medical Reference

Reviewed by Joseph Goldberg, MD on October 18, 2014

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