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    Tricyclic Antidepressants for Bipolar Disorder

    Older tricyclic antidepressants used for treating bipolar disorder may be more likely to trigger a manic episode or rapid cycling than other depression drugs. They also tend to have more side effects than newer generation antidepressants, and can be especially dangerous in overdose. However, they are occasionally still used when other antidepressants are not effective, or when certain other conditions (such as migraine or neuropathic pain disorders) are also present. Like all antidepressants, experts recommend against taking a tricyclic medication without a mood stabilizer (such as lithium or divalproex) to minimize the chance of inducing mania symptoms.

    Tricyclic antidepressants include:

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    Treatments for Mania in Bipolar Disorder

    Bipolar disorder is a serious mood disorder that affects more than 10 million Americans. Unlike unipolar depression, bipolar disorder is equally common in men and women. The onset of the condition typically occurs in the early 20s, but (although rare) the first symptoms can appear in early childhood or late in life. Although some people may have only one episode, bipolar disorder is a lifelong condition that usually involves recurrent episodes. It's usually marked by episodes of mania or hypomania...

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    Tricyclic antidepressants work by increasing levels of the mood chemicals serotonin and norepinephrine in the brain. However, because they may sometimes increase the risk of mania or rapid cycling -- as well as heart problems if you take heart medication -- these drugs are less often recommended for bipolar disorder.

    WebMD Medical Reference

    Reviewed by Joseph Goldberg, MD on October 18, 2014

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