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Autism Spectrum Disorders Health Center

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Chelation Study for Autism Called Off

Controversial Trial Too Risky, Panel Says
WebMD Health News
Reviewed by Louise Chang, MD

Sept. 18, 2008 -- Federal officials have abandoned a proposed study of a controversial alternative therapy for autism, leaving parents who believe in the treatment disappointed and angry about the move.

In a statement released Wednesday, the National Institute of Mental Health (NIMH) says its investigators would not go forward with a trial of chelation (pronounced kee-LAY-shun) therapy that has been discussed for the past two years.

The decision was made after the federal review board that originally approved the study reversed its position.

The study had reportedly been on hold since last year when animal trials linked a specific chelation treatment to brain damage in rats.

"The Board determined that there was no clear evidence for direct benefit to children who would participate in the chelation trial and that the study presents more than a minimal risk," according to the NIMH statement.

Chelation for Autism

Chelation therapy involves the administration of agents to remove heavy metals from the blood, usually, but not always, by intravenous infusion.

The therapy has been approved for more than 50 years for the treatment of lead poisoning, but it is not approved for the treatment of autism.

Nevertheless, many parents who believe their children's autism was caused by mercury exposure from a preservative once common in childhood vaccines have embraced chelation therapy.

"Our phones have been ringing off the hook since this was announced," Rebecca Estepp of the autism support group Talk About Curing Autism tells WebMD.

"We are dumbfounded and saddened that this study of a promising autism treatment will not happen. The government has pulled the rug out from under us with no explanation."

Estepp, whose 10-year-old son is autistic, says she knows of thousands of children who have improved and even had their autism symptoms disappear following chelation therapy.

"Do we have to have thousands more before they take us seriously?" she asks. "When does the anecdotal evidence get so large that they have to listen to us?"

A Chelation Death Reported

The use of chelation therapy as a treatment for autism has been linked to at least one death in 2005 of a 5-year-old boy who was treated with an agent that is not widely used in children.

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