Chelation Study for Autism Called Off
Controversial Trial Too Risky, Panel Says
Sept. 18, 2008 -- Federal officials have abandoned a proposed study of a
controversial alternative therapy for autism, leaving parents who
believe in the treatment disappointed and angry about the move.
In a statement released Wednesday, the National Institute of Mental Health
(NIMH) says its investigators would not go forward with a trial of chelation (pronounced kee-LAY-shun) therapy that has
been discussed for the past two years.
The decision was made after the federal review board that originally
approved the study reversed its position.
The study had reportedly been on hold since last year when animal trials
linked a specific chelation treatment to brain damage in rats.
"The Board determined that there was no clear evidence for direct
benefit to children who would participate in the chelation trial and that the
study presents more than a minimal risk," according to the NIMH
Chelation for Autism
Chelation therapy involves the administration of agents to remove heavy
metals from the blood, usually, but not always, by intravenous infusion.
The therapy has been approved for more than 50 years for the treatment of
lead poisoning, but it is not approved for the treatment of autism.
Nevertheless, many parents who believe their children's autism was caused by
mercury exposure from a preservative once common in childhood vaccines have
embraced chelation therapy.
"Our phones have been ringing off the hook since this was
announced," Rebecca Estepp of the autism support group Talk About Curing
Autism tells WebMD.
"We are dumbfounded and saddened that this study of a promising autism
treatment will not happen. The government has pulled the rug out from under
us with no explanation."
Estepp, whose 10-year-old son is autistic, says she knows of thousands of
children who have improved and even had their autism
symptoms disappear following chelation therapy.
"Do we have to have thousands more before they take us seriously?"
she asks. "When does the anecdotal evidence get so large that they have to
listen to us?"
A Chelation Death Reported
The use of chelation therapy as a treatment for autism has been linked to at
least one death in 2005 of a 5-year-old boy who was treated with an agent that
is not widely used in children.
In the statement released yesterday, NIMH officials noted that approval by
the Department of Health and Human Services (DHHS) was needed to proceed with
the trial. But NIMH will not ask the DHHS to review the study protocol, a
process that could take as long a year.
"Given the time and resources required for this additional approval
process, NIMH has decided to use its intramural program to test other
interventions for autism and will not pursue the required DHHS review," the
Physician Paul Offit, MD, who this month published a book that is critical
of alternative treatments, applauds the NIMH decision.