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Autism Spectrum Disorders Health Center

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Autism Linked to Unusual Shapes in Lungs

Study Shows Children Born With a Unique Airway Shape May Have Autism
WebMD Health News
Reviewed by Laura J. Martin, MD

Oct. 25, 2011 (Honolulu) -- Children born with a certain shape in their airways -- the tubes that take air to the lungs -- all have autism or autism spectrum disorder, according to a new study.

The study is one of the few to show a strong link between anatomy and autism and may indicate a genetic cause for the syndrome, says Barbara Stewart, MD. She presented the study today at CHEST 2011, the Annual Meeting of the American College of Chest Physicians.

"I think it takes some of the pressure off parents," Stewart tells WebMD. "Autism is not something they did. It just happened."

Stewart, a lung doctor at Nemours Children's clinic in Pensacola, Fla., made the discovery while examining patients referred to her for persistent coughs.

Searching for the cause of their coughs, she examined the passages that take air to the lungs by placing a tiny camera down their windpipes, a procedure known as bronchoscopy. In looking at the lungs in this way, she noticed that several patients had divisions in some of their airways, creating double passages, which she calls "doublets."

Then she noticed that these patients all had something else in common: "Every single one has autism, or autism spectrum disorder," she says.

Stewart says it's possible that the doublets cause more resistance to the air passing into the lungs; these patients tend to be short of breath. But she doesn't think that these patients' breathing problems could be enough to cause any brain damage that might lead to autism.

"I think the whole thing occurs embryologically -- when the cell and egg come together and the fetus is formed," she says. "It's important for parents to know that."

While the information points in new directions for research, there is nothing that parents can or should do with the information, Stewart says. She does not recommend that parents of autistic children have bronchoscopies to see if the doublets are present.

Anatomy and Autism

Altogether, Stewart evaluated 49 children with autism or ASD. That is a small number on which to make any conclusions, Joseph Horrigan, MD, tells WebMD. Horrigan is assistant vice president for medical research at Autism Speaks, a foundation that researchers the disorder.

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