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Autism Spectrum Disorders Health Center

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Kids With Autism May Find Human Voice Unpleasant

MRI shows weaker connection to brain's reward center in those who have high-functioning autism

WebMD News from HealthDay

By Amy Norton

HealthDay Reporter

MONDAY, June 17 (HealthDay News) -- A new brain-imaging study could help explain why children with autism have difficulty with verbal communication: They may not get much pleasure from the human voice.

Researchers found that those with the disorder showed weaker connections between the brain's voice-processing areas and its "reward" centers compared to those without.

That suggests that kids with autism do not get the same pleasure from the human voice that typically developing children do, researchers said.

"When we speak, we don't only convey information, we convey emotion and social cues," said Daniel Abrams, a researcher at Stanford University in Palo Alto, Calif., who led the new study.

It's well known that children with autism have difficulty reading those cues and having conversations. And children with more severe autism may be completely indifferent to the sound of the human voice.

There are competing theories on why that is, Abrams said. "One theory is that, although these children have normal hearing, there's a problem in the brain's sound processing," he explained.

Another theory is that "social cues," including other people's speech, don't hit the brain's reward system in the typical way. "Our findings support this idea," Abrams said. "There may be some deficit in the brain circuitry related to reward."

The findings, published online Monday in the Proceedings of the National Academy of Sciences, are based on a type of brain imaging called functional MRI, which allows researchers to measure brain activity by watching changes in blood flow.

The investigators took scans of 20 children who were on average 10 years old and had "high-functioning" autism: all had normal IQs and speaking and reading skills, but had trouble conversing and grasping "emotional cues" in other people's voices. The researchers also scanned 19 kids without autism who were in the same age and IQ range.

The researchers found that the children with autism showed a weaker connection between an area of the brain that responds to the human voice and two other brain regions that release the "feel-good" chemical dopamine in response to rewards.

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