Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Autism Spectrum Disorders Health Center

Font Size

Environmental Changes to Genes & Kids With Autism

Double whammy of mutated genes and environmental genetic changes may make disorder more severe

WebMD News from HealthDay

By Mary Elizabeth Dallas

HealthDay Reporter

THURSDAY, May 29, 2014 (HealthDay News) -- New research appears to confirm that environmental influences on genes, and not just gene mutations, play a role in the development of autism.

Scientists from Albert Einstein College of Medicine of Yeshiva University in New York City said this may help explain why older pregnant women are at greater risk for having a baby with autism.

Previous research has suggested that gene mutations account for only about half of the risk for developing autism, the study authors pointed out.

Scientists know that men who are older than 40 are at greater risk for having a child with autism because of genetic mutations that accumulate over the years in sperm-making cells. Women who are 35 and older also face a greater chance for having a child with autism. The reason why, however, has been unclear.

In conducting the study, the researchers looked at environmental changes to genes that could help explain this increased risk, such as conditions in the mother's uterus, stress and diet. These types of changes are called epigenetic changes.

The study, published online May 29 in the journal PLOS Genetics, involved 47 children with autism spectrum disorder (ASD) and 48 typically developing children of women aged 35 and older. The kids lived throughout the United States, as well as in Chile and Israel.

To look for differences in genes between the children, the researchers analyzed cells that lined their cheeks (the buccal epithelium).

"We hypothesized that whatever influences lead to ASD in children of older women probably are already present in the reproductive cells that produce the embryo or during the very earliest stages of embryonic development in cells that give rise to both the buccal epithelium and the brain," study senior author Dr. John Greally, director of the Center for Epigenomics at Einstein, said in a news release.

The researchers first examined the children's cheek cell samples for abnormal chromosome numbers, as well as other chromosomal defects. None of these abnormalities were found in the cheek cells of the children with autism or the typically developing children.

Today on WebMD

girl at window
Symptoms within the first 2 years of a child’s life.
boy playing a violin
How is this condition similar to autism?
Mother and daughter indoors playing
Play therapy may undo the disorder in at-risk babies.
preschool age girl sitting at desk
What causes this rare form of autism?
High Functioning Autism And Asperge Syndrome
Gluten Free Diet Slideshow
Mother and daughter indoors playing
man on bicycle
girl at window
Mother hugging teenage son
Understanding Rett Syndrome
Home Care Tips

WebMD Special Sections