Brain & Nervous System Health Center
Machado-Joseph Disease
Important
It is possible that the main title of the report Machado-Joseph Diseaseis not the name you expected.
Synonyms
- Autosomal Dominant Spinocerebellar Degeneration
- Azorean Neurologic Disease
- Machado Disease
- Joseph Disease
- MJD
- Nigrospinodentatal Degeneration
- Striatonigral Degeneration, Autosomal Dominant Type
- Spinocerebellar Ataxia Type III (SCA 3)
Disorder Subdivisions
- Machado-Joseph Disease Type I (MJD-I)
- Machado-Joseph Disease Type II (MJD-II)
- Machado-Joseph Disease Type III (MJD-III)
General Discussion
Machado-Joseph Disease (MJD-III), also called spinocerebellar ataxia type III, is a rare, inherited, ataxia (lack of muscular control) affecting the central nervous system and characterized by the slow degeneration of particular areas of the brain called the hindbrain. Patients with MJD may eventually become crippled and/or paralyzed but their intellect remains intact. The onset of symptoms of MJD varies from early teens to late adulthood.
Three forms of Machado-Joseph Disease are recognized: Types MJD-I, MJD-II, and MJD-III. The differences in the types of MJD relate to the age of onset and severity. Earlier onset usually produces more severe symptoms.
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Resources
WE MOVE (Worldwide Education and Awareness for Movement Disorders)
204 West 84th Street
New York
NY
10024
USA
Tel: (212)875-8312
Fax: (212)875-8389
wemove@wemove.org
http://www.wemove.org
National Ataxia Foundation
2600 Fernbrook Lane n, Suite 119
Minneapolis
MN
55447-4752
USA
Tel: (763)553-0020
Fax: (763)553-0167
naf@ataxia.org
http://www.ataxia.org
International Joseph Disease Foundation, Inc.
P.O. Box 994268
Redding
CA
96099
USA
Tel: (530)246-4722
Fax: (530)232-2773
MJD@ijdf.net
http://www.ijdf.net
National Institute of Neurological Disorders and Stroke (NINDS)
31 Center Drive
8A07
Bethesda
MD
20892-2540
Tel: (301)496-5751
Fax: (301)402-2186
800: (800)352-9424
braininfo@ninds.nih.gov
http://www.ninds.nih.gov/
Rosenberg, Roger N., M.D.
Department of Neurology and Physiology
University of Texas Southwestern Medical School
5323 Harry Hines Blvd.
Dallas
TX
75235-9036
Tel: (214)688-4800MUMS (Mothers United for Moral Support, Inc) National Parent-to-Parent Network
150 Custer Court
Green Bay
WI
54301-1243
USA
Tel: (920)336-5333
Fax: (920)339-0995
800: (877)336-5333
mums@netnet.net
http://www.netnet.net/mums/
For a Complete Report:
This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org
Last Updated: 5/23/2008
Copyright 1986, 1989, 1990, 1993, 1994, 1996, 1997, 2003 National Organization for Rare Disorders, Inc.
WebMD Medical Reference from the National Organization of Rare Disorders
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