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    Multiple System Atrophy

    Important
    It is possible that the main title of the report Multiple System Atrophy is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

    Synonyms

    • MSA
    • progressive autonomic failure with multiple system atrophy
    • Shy-Drager syndrome (SDS)
    • sporadic olivopontocerebellar atrophy (sOPCA)
    • striatonigral degeneration (SND

    Disorder Subdivisions

    • MSA-C (cerebellar phenotype)
    • MSA-P (parkinsonian phenotype)

    General Discussion

    Summary
    Multiple system atrophy (MSA) is a rare sporadic progressive neurological disorder characterized by a varying combination of symptoms and signs. Onset is during adulthood (>30 years). Affected individuals may experience symptoms similar to those found in Parkinson's disease (parkinsonism); cerebellar signs such as progressive impairment of the ability to coordinate voluntary movements (cerebellar ataxia); and impaired functioning of the portion of the nervous system (autonomic nervous system) that regulates certain involuntary body functions (autonomic failure) such as heart rate, blood pressure, sweating, and bowel and bladder control. When parkinsonian symptoms predominate, the disorder may be referred to as MSA-P (parkinsonian phenotype); when the cerebellar symptoms predominate the disorder may be referred to as MSA-C (cerebellar phenotype). The exact cause of MSA is unknown.

    Introduction
    The term multiple system atrophy was first introduced in the medical literature in 1969. It encompasses three presentations of a single disease formerly thought to be separate disorders, specifically Shy-Drager syndrome (which emphasized autonomic dysfunction), striatonigral degeneration (which emphasized parkinsonian symptoms), and sporadic olivopontocerebellar atrophy (which emphasized cerebellar symptoms), although the cases of each of these that were originally described presented a combination of all three clinical features, and brain pathology was found in both the striatonigral and olivopontocerebellar structures. Additionally, there is a hereditary form of olivopontocerebellar atrophy that is not part of the multiple system atrophy spectrum.

    Resources

    WE MOVE (Worldwide Education and Awareness for Movement Disorders)
    5731 Mosholu Avenue
    Bronx, NY 10471
    USA
    Tel: (347)843-6132
    Fax: (718)601-5112
    Email: wemove@wemove.org
    Internet: http://www.wemove.org

    Parkinson's Disease Foundation, Inc.
    1359 Broadway
    Suite 1509
    New York, NY 10018
    Tel: (212)923-4700
    Fax: (212)923-4778
    Tel: (800)457-6676
    Email: info@pdf.org
    Internet: http://www.pdf.org

    National Ataxia Foundation
    2600 Fernbrook Lane Suite 119
    Minneapolis, MN 55447
    USA
    Tel: (763)553-0020
    Fax: (763)553-0167
    Email: naf@ataxia.org
    Internet: http://www.ataxia.org

    CurePSP: Foundation for PSP l CBD & Related Brain Diseases
    30 E. Padonia Road, Suite 201
    Timonium, MD 21093
    Tel: (410)785-7004
    Fax: (410)785-7009
    Tel: (800)457-4777
    Email: info@curepsp.org
    Internet: http://www.curepsp.org

    NIH/National Institute of Neurological Disorders and Stroke
    P.O. Box 5801
    Bethesda, MD 20824
    Tel: (301)496-5751
    Fax: (301)402-2186
    Tel: (800)352-9424
    TDD: (301)468-5981
    Internet: http://www.ninds.nih.gov/

    Vanderbilt's Autonomic Dysfunction Center
    Vanderbilt University Medical Center
    1211 Medical Center Drive
    Nashville, TN 37232-2195
    USA
    Tel: (615)322-5000
    Fax: (615)343-8649
    Email: david.robertson@vanderbilt.edu
    Internet: http://www.mc.vanderbilt.edu/gcrc/adc

    National Dysautonomia Research Foundation
    PO Box 301
    Red Wing, MN 55066-0102
    Tel: (651)327-0367
    Email: ndrf@ndrf.org
    Internet: http://www.ndrf.org

    Genetic and Rare Diseases (GARD) Information Center
    PO Box 8126
    Gaithersburg, MD 20898-8126
    Tel: (301)251-4925
    Fax: (301)251-4911
    Tel: (888)205-2311
    TDD: (888)205-3223
    Internet: http://rarediseases.info.nih.gov/GARD/

    SDS/MSA Support Group
    8311 Brier Creek Parkway Suite 105-434
    Raleigh, NC 27617
    Tel: (866)737-4999
    Email: Vjames@shy-drager.org or jbiedenharn@shy-drager.org
    Internet: http://www.shy-drager.org

    National Parkinson Foundation, Inc.
    1501 NW 9th Ave/Bob Hope Road
    Miami, FL 33136-1494
    Tel: (305)243-6666
    Fax: (305)243-6073
    Tel: (800)327-4545
    Email: contact@parkinson.org
    Internet: http://www.parkinson.org

    Movement Disorder Society
    555 E. Wells Street
    Suite 1100
    Milwaukee, WI 53202-3823
    Tel: (414)276-2145
    Fax: (414)276-3349
    Email: info@movementdisorders.org
    Internet: http://www.movementdisorders.org

    For a Complete Report:

    This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

    The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

    It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

    This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

    For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

    Last Updated: 1/15/2013
    Copyright 1986, 1987, 1988, 1991, 1992, 1994, 1998, 1999, 2000, 2003, 2013 National Organization for Rare Disorders, Inc.

    WebMD Medical Reference from the National Organization for Rare Disorders

    Last Updated: May 28, 2015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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