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    Implant Aids Man With Brain Injury

    Deep Brain Stimulation Helps Patient in Minimally Conscious State to Talk, Eat Again
    WebMD Health News
    Reviewed by Louise Chang, MD

    Aug. 1, 2007 -- Tomorrow's edition of the journal Nature includes what doctors call the "remarkable" case of a brain-injured man helped by deep brain stimulation.

    The 38-year-old man had been in a "minimally conscious state" for six years after suffering a severe traumatic brain injury in an assault. After getting deep brain stimulation, he is now able to talk and eat on his own. His family has requested that his name not be released.

    A minimally conscious state is different from a coma or a persistent vegetative state. Patients in a minimally conscious state occasionally show signs of arousal and organized behavior, but they have a "profound deficit in consciousness," states an editorial published in Nature.

    Despite rehabilitation therapy, the man was nonverbal and couldn't swallow or communicate reliably.

    "He infrequently mouthed single words when prompted but could not communicate yes/no responses reliably," write the researchers, who included Nicholas Schiff, MD, of New York's Weill Cornell Medical College.

    But the man's brain scans showed that while he had severe brain damage, some of the networks within his brain were still intact.

    Based on those brain scans, Schiff's team asked the man's family to let the man try deep brain stimulation.

    Patient Improves With Deep Brain Stimulation

    The doctors surgically implanted electrodes in the man's brain, targeting a brain area called the thalamus. Two days after surgery, the doctors turned the electrodes on as an initial test of deep brain stimulation.

    When they did that, the man was able to keep his eyes open longer than before the surgery, and he was able to turn his head when someone spoke.

    Over the next six months, the doctors gradually gave the man deep brain stimulation. He gained the ability to chew and swallow food and to talk more, even occasionally saying sentences up to six words long.

    The man's improvements didn't disappear on days when he didn't get deep brain stimulation, and his ongoing rehabilitation therapy didn't appear to explain his progress, note the researchers.

    Schiff and colleagues caution that other patients with severe traumatic brain injuries may not respond the same way to deep brain stimulation. They call for further studies on deep brain stimulation for patients with severe traumatic brain injury.

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