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Brain & Nervous System Health Center

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EEG Measures Awareness in Some 'Vegetative’ Patients

Study: 1 in 5 Patients Diagnosed as Vegetative Showed Brain Activity Response to Verbal Commands

Patients Answered ‘Yes’ and ‘No’ continued...

In their earlier studies, the researchers used functional MRI to image the brains of vegetative patients, finding that some patients showed evidence of consciousness that could only be identified with the test.

One such patient was a man in his late 20s who had been in a coma for two years following a car accident before entering what was believed to be a persistent vegetative state.

The man appeared to be awake and blinked occasionally, but otherwise showed no signs of awareness.

Owen and colleagues asked him simple questions while his brain was being scanned. They instructed him to imagine playing tennis to answer “yes” to a question and imagine walking around his home to answer “no”.

They chose the two images because tennis movements activate regions at the top of the brain associated with spatial activities, while navigation activates areas at the base of the brain.

Using MRI, Owen’s group and another research team identified four patients out of 23 tested (17%) who seemed to be able to respond even though they had been diagnosed as being in a vegetative state.

1 in 4 Study Participants Without Brain Damage ‘Failed’ Test

The new study, published in The Lancet Online First, was conducted to determine if EEG testing, which is much cheaper and easier to administer than functional MRI, could also detect awareness in seemingly unaware patients with brain damage.

It included 16 patients thought to be in vegetative states and 12 people who had no brain damage who served as a comparison group.

This time Owen, Cruse, and colleagues used imagery of movements to assess EEG responses, asking patients and healthy study participants to imagine moving their right hand and toes to respond to different commands.

Cruse tells WebMD that three of the patients, or 19%, generated the appropriate EEG responses to the two different commands more times than would have been expected by chance.

One in four of the healthy study participants, the ones with no brain damage, did not do as well, and were not able to consistently generate the appropriate electrical activity patterns.

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