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Progressive Multifocal Leukoencephalopathy
Important
It is possible that the main title of the report Progressive Multifocal Leukoencephalopathyis not the name you expected.
Disorder Subdivisions
- None
General Discussion
Progressive multifocal leukoencephalopathy (PML) is a neurological disorder characterized by destruction of the myelin, an oily substance that helps protect nerve cells in the brain and spinal cord, also known as central nervous system (CNS) white matter. It is caused by a virus called JC virus (JCV), named after the initials of the patient in whom it was first discovered. The virus is widespread, found in at least 85% of the general adult population. It remains inactive in healthy individuals and causes disease only when the immune system has been severely weakened, such as in people with HIV/AIDS, or hematological malignancies, and in organ transplant recipients who receive immuno- suppressant medications to avoid rejection of the transplanted organ. Altogether, PML occurs in approximately one in 200,000 people.
The term "progressive" in PML means that the disease continues to get worse and often leads to serious brain damage. The term "multifocal" means that JCV causes disease in multiple parts of the brain. However, it is possible for an individual with PML to have only one brain lesion instead of several lesions. The term "leukoencephalopathy" means that the disease affects mainly the white matter of the brain or myelin, although there are some rare cases in which the gray matter neurons is also involved.
Resources
amfAR (American Foundation for AIDS Research)
120 Wall Street
Thirteenth Floor
New York
NY
10005-3902
USA
Tel: (212)806-1600
Fax: (212)806-1601
800: (800)392-6327
webmaster@amfar.org
http://www.amfar.org
Centers for Disease Control and Prevention
1600 Clifton Road NE
Atlanta
GA
30333
Tel: (404)639-3534
800: (800)311-3435
http://www.cdc.gov/netinfo.htm
http://www.cdc.gov/
Gay Men's Health Crisis
119 West 24th Street
9th Floor
New York
NY
10011
Tel: (212)367-1211
Fax: (212)367-1236National Institute of Neurological Disorders and Stroke (NINDS)
31 Center Drive
8A07
Bethesda
MD
20892-2540
Tel: (301)496-5751
Fax: (301)402-2186
800: (800)352-9424
braininfo@ninds.nih.gov
http://www.ninds.nih.gov/
HIV/AIDS Treatment Information Service
P.O. Box 6303
Rockville
MD
20849-6303
Tel: (301)519-0459
Fax: (301)519-6616
800: (800)448-0440
TDD: (888)480-3739
atis@hivatis.org
http://www.hivatis.org
AIDS Clinical Trials Information Service
1600 Research Boulevard
P.O. Box 6421
Rockville
MD
20849-6421
Tel: (301)251-5160
Fax: (301)738-6616
800: (800)448-0440
TDD: (800)243-7012
actis@cdcnac.org
http://www.actis.org
For a Complete Report:
This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org
Last Updated: 4/11/2008
Copyright 2006 National Organization for Rare Disorders, Inc.
WebMD Medical Reference from the National Organization of Rare Disorders
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