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Restless Legs Syndrome Center

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Ten Common Questions About Restless Legs Syndrome

What Causes Restless Legs Syndrome?

Restless legs syndrome's cause is usually unknown. Leading experts suspect that in people with restless legs syndrome, also called RLS, the brain takes up or uses iron abnormally.

Genetics also plays a key role. About half of those with restless legs syndrome have family members affected, too.

Many medical conditions are associated with restless legs syndrome, including iron deficiency, diabetes, end-stage kidney disease, Parkinson's disease, and even pregnancy. These cases account for a minority of people with restless legs syndrome, however. Treating these conditions, if present, can improve restless legs syndrome symptoms.

Some medicines, such as antipsychotic drugs -- like aripiprazole (Abilify) and risperidone (Risperdal) -- also can cause involuntary leg movements similar to RLS.

Who Gets Restless Legs Syndrome?

No one knows the true number of people with restless legs syndrome. About 10% of the population is affected, and about 2% to 3% have moderate to severe symptoms that affect their quality of life. We do know that:

  • Women are affected slightly more often than men.
  • Most people with severe disease are middle-aged or older.
  • Those with affected family members usually get restless legs syndrome at a younger age, but it progresses more slowly.

Does Restless Legs Syndrome Ever Go Away by Itself?

There are reported cases of spontaneous remissions of restless legs syndrome. However, they are rare. RLS is a progressive disease for most people, with symptoms getting gradually worse over time."

For those with restless legs symptoms caused by a medical condition, treatment of that condition can relieve or improve their restless legs syndrome.

Can Restless Legs Syndrome Develop Into Something More Serious?

Most people with restless legs syndrome have the "idiopathic" form -- meaning there's no known cause. Consequently, there is no risk of RLS progressing to more serious conditions, such as Parkinson's disease.

Restless legs syndrome can also be caused by medical conditions or diseases (such as iron deficiency, diabetes, or kidney disease). If untreated, these medical conditions can cause serious health problems as well as worsen the symptoms of restless legs syndrome.

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