The specific causes of restless legs syndrome (RLS) are not known. Disease in the blood vessels of the legs or in the nerves in the legs that control leg movement and sensation was once thought to cause RLS, but both of these suggestions have been rejected.
RLS may be related to abnormalities in brain chemicals (neurotransmitters) that help regulate muscle movements, or to abnormalities in the part of the central nervous system that controls automatic movements. Research is still being done in these areas.
Recommended Related to Restless Leg Syndrome (RLS)
Restless legs syndrome, or RLS, is a common nerve condition where you have unpleasant creeping, tugging, or pulling feelings in your legs. You might also have an overwhelming urge to move your legs. The symptoms are usually worse at night or when you're resting.
Doctors don't know the cause of RLS, and there’s no cure. But certain things can trigger symptoms. Knowing your triggers and how to avoid them will help.
Possible triggers include:
Medication -- Your prescription or non-prescription...
RLS can sometimes be caused by an underlying medical condition (secondary RLS); however, most of the time the cause is not clear.
What Medical Conditions Are Linked to RLS?
Many different medical conditions have been linked to RLS. The two most common conditions are iron-deficiency anemia (low blood count) and peripheral neuropathy (damage to the nerves of the arms and legs, often caused by underlying conditions such as diabetes).