The specific causes of restless legs syndrome (RLS) are not known. Disease in the blood vessels of the legs or in the nerves in the legs that control leg movement and sensation was once thought to cause RLS, but both of these suggestions have been rejected.
RLS may be related to abnormalities in brain chemicals (neurotransmitters) that help regulate muscle movements, or to abnormalities in the part of the central nervous system that controls automatic movements. Research is still being done in these areas.
Recommended Related to Restless Leg Syndrome (RLS)
Restless legs syndrome (RLS) steals sleep. It's usually worst in the evening and overnight, which can mean little rest, and fatigue the next day.
"Most people with RLS have fragmented sleep, with difficulty falling asleep and repetitive jerking motions that can wake them up," says neurologist Nancy Foldvary-Schaefer, DO, director of the Cleveland Clinic's Sleep Disorders Center.
The good news, she says, is that many people with RLS respond to simple treatments -- and that can mean better sleep...
RLS can sometimes be caused by an underlying medical condition (secondary RLS); however, most of the time the cause is not clear.
What Medical Conditions Are Linked to RLS?
Many different medical conditions have been linked to RLS. The two most common conditions are iron-deficiency anemia (low blood count) and peripheral neuropathy (damage to the nerves of the arms and legs, often caused by underlying conditions such as diabetes).
Other medical conditions linked to RLS include:
Hyper- or hypothyroidism (over- or underactive thyroid glands)
Vitamin and mineral deficiency, such as magnesium deficiency and vitamin B-12 deficiency
Severe kidney disease and uremia (kidney failure causing build up of toxins within the body)
Amyloidosis (build-up of a starch-like substance in the body's tissues and organs)