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    Clinical Trials for Breast Cancer

    Should you or shouldn't you? Weighing the pros and cons of joining a breast cancer clinical trial.

    WebMD Feature

    Only about 3% of women with breast cancer take part in clinical trials, according to Y-ME, the national breast cancer organization.

    This low level of clinical research participation may be stalling treatment progress. The fewer women who join clinical trials, the longer it takes to get data about whether a new treatment is an improvement over existing ones.

    Should you join a breast cancer clinical trial? If you do, how can you choose the best one for you?

    "Patients should be biased toward clinical trials," says Clifford Hudis, MD, Chief of the Breast Cancer Medicine Service at Memorial Sloan-Kettering Cancer Center in New York. "If you [are seen at a medical] center and they have a trial for which you're appropriate, you should seriously consider it."

    What are the advantages of participating in a clinical trial?

    • You'll have access to the latest treatments before they're widely available. "Your list of available treatment options is finite, and clinical trials will sometimes represent options that don't exist outside the trial," says Hudis.
    • You'll receive expert care and close monitoring. Although all women with breast cancer are monitored closely, clinical trial members are likely to receive an even higher level of scrutiny.
    • You'll be contributing to the advancement of medical research that may benefit not only you, but many other women -- maybe even your own daughters and granddaughters.

    Does that mean that there are no down sides to participating in clinical trials? Of course not. "Any time you're trying a new treatment or one with which we have less experience, there's always some potential for greater risk," says Eric Winer, MD, director of the Breast Program at Boston's Dana-Farber Cancer Institute.

    Potential negatives include:

    • The new treatment may not work as well as existing treatments.
    • The new treatment may involve more difficult side effects than existing treatments.
    • The trial may involve more work for you. Being in a clinical trial might mean additional appointments, extra blood draws or imaging studies, and more paperwork, for example.

    You may think that if you're not being treated at a major, nationally known cancer center such as Sloan-Kettering or Dana-Farber, you won't have the opportunity to participate in clinical trials. Not true.

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