Triple-negative breast cancer (TNBC) is defined as the absence of staining for estrogen receptor,progesterone receptor,and HER2/neu. TNBC is insensitive to some of the most effective therapies available for breast cancer treatment including HER2 -directed therapy such as trastuzumab and endocrine therapies such as tamoxifen or the aromatase inhibitors. Combination cytotoxic chemotherapy ...
Note: Separate PDQ summaries on Breast Cancer Prevention, Breast Cancer Treatment, Male Breast Cancer Treatment, and Breast Cancer Treatment and Pregnancy are also available.This summary covers the topic of breast cancer screening and includes information about breast cancer incidence and mortality, risk factors for breast cancer, the process of breast cancer diagnosis, and the benefits and harms of various breast cancer screening modalities. This summary also includes information about screening among special populations.Mammography is the most widely used screening modality, with solid evidence of benefit for women aged 40 to 74 years. Clinical breast examination and breast self-exam have also been evaluated but are of uncertain benefit. Technologies such as ultrasound, magnetic resonance imaging, tomosynthesis, and molecular breast imaging are being evaluated, usually as adjuncts to mammography.Screening With MammographyBenefitsBased on solid evidence, screening mammography may
Ductal Carcinoma In Situ (DCIS) Treatment of ductal carcinoma in situ (DCIS) may include the following: Breast-conserving surgery with or without radiation therapy or hormone therapy. Total mastectomy with or without hormone therapy. Clinical trials testing breast-conserving surgery and hormone therapy with or without radiation therapy. This summary section refers to specific treatments under .
PDQ IS A COMPREHENSIVE CANCER DATABASE AVAILABLE ON NCI'S WEB SITE. PDQ is the National Cancer Institute's (NCI's) comprehensive cancer information database. Most of the information contained in PDQ is available online at NCI's Web site. PDQ is provided as a service of the NCI. The NCI is part of the National Institutes of Health,the federal government's focal point for biomedical research. .
Breast cancer is a disease in which malignant (cancer) cells form in the tissues of the breast. The breast is made up of lobes and ducts. Each breast has 15 to 20 sections called lobes,w hich have many smaller sections called lobules. Lobules end in dozens of tiny bulbs that can produce milk. The lobes,lobules,and bulbs are linked by thin tubes called ducts.