Breast Cancer Prevention (PDQ®): Prevention - Health Professional Information [NCI] - nci_ncicdr0000062779-nci-header
This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http://cancer.gov or call 1-800-4-CANCER.Breast Cancer Prevention
Breast Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Stage IIIB, Inoperable IIIC, IV, Recurrent, and Metastatic Breast Cancer
Inoperable Stage IIIB or IIIC or Inflammatory Breast CancerMultimodality therapy delivered with curative intent is the standard of care for patients with clinical stage IIIB disease. In a retrospective series, approximately 32% of patients with ipsilateral supraclavicular node involvement and no evidence of distant metastases (pN3c) had prolonged disease-free survival (DFS) at 10 years with combined modality therapy. Although these results have not been replicated in another series, this result suggests such patients should be treated with the same intent. Initial surgery is generally limited to biopsy to permit the determination of histology, estrogen-receptor (ER) and progesterone-receptor (PR) levels, and human epidermal growth factor receptor 2 (HER2/neu) overexpression. Initial treatment with anthracycline-based chemotherapy and/or taxane-based therapy is standard.[2,3] In one series of 178 patients with inflammatory breast cancer, DFS
Breast Cancer Treatment and Pregnancy (PDQ®): Treatment - Patient Information [NCI] - Treatment Option Overview
There are different types of treatment for patients with breast cancer. Different types of treatment are available for patients with breast cancer. Some treatments are standard (the currently used treatment),and some are being tested in clinical trials. Before starting treatment,patients may want to think about taking part in a clinical trial. A treatment clinical trial is a research study ...
Male Breast Cancer Treatment (PDQ®): Treatment - Patient Information [NCI] - To Learn More About Male Breast Cancer
For more information from the National Cancer Institute about male breast cancer,see the following: Breast Cancer Home Page Understanding Cancer Series: Gene Testing Genetic Testing for Breast and Ovarian Cancer Risk: It's Your Choice For general cancer information and other resources from the National Cancer Institute,see the following: What You Need to Know About™ Cancer - An Overview ...
Breast Cancer Screening (PDQ®): Screening - Patient Information [NCI] - What is screening?
Screening is looking for cancer before a person has any symptoms. This can help find cancer at an early stage. When abnormal tissue or cancer is found early,it may be easier to treat. By the time symptoms appear,cancer may have begun to spread. Scientists are trying to better understand which people are more likely to get certain types of cancer. They also study the things we do and the ...
Breast Cancer Screening (PDQ®): Screening - Health Professional Information [NCI] - Description of the Evidence
BackgroundBreast cancer incidence and mortalityBreast cancer is the most common noncutaneous cancer in U.S. women, with an estimated 64,640 cases of in situ disease, 232,340 new cases of invasive disease, and 39,620 deaths expected in 2013. Thus, fewer than 1 of 6 women diagnosed with breast cancer die of the disease. By comparison, about 72,220 American women are estimated to die of lung cancer in 2013. Males account for 1% of breast cancer cases and breast cancer deaths (refer to the Special Populations section of this summary for more information).Widespread adoption of screening increases breast cancer incidence in a given population and changes the characteristics of cancers detected, with increased incidence of lower-risk cancers, premalignant lesions, and ductal carcinoma in situ (DCIS). (Refer to the Ductal Carcinoma In Situ section in the Breast Cancer Diagnosis and Pathology section of this summary for more information.) Ecologic studies from the United States  and
Male Breast Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Treatment Options for Male Breast Cancer
Initial surgical management Primary standard treatment is a modified radical mastectomy with axillary dissection.[ 1,2,3 ] Responses are generally similar to those seen in women with breast cancer.[ 2 ] (Refer to the PDQ summary on Breast Cancer Treatment for more information.) Adjuvant therapy In men with node-negative tumors,adjuvant therapy should be considered on the same basis as for a ...
Breast Cancer Treatment and Pregnancy (PDQ®): Treatment - Patient Information [NCI] - Treatment Options by Stage
Early Stage Breast Cancer (Stage I and Stage II) Treatment of early stage breast cancer (stage I and stage II) may be surgery followed by adjuvant therapy as follows: Modified radical mastectomy. Breast-conserving surgery: Lumpectomy,partial mastectomy or segmental mastectomy. Breast-conserving surgery during pregnancy followed by radiation therapy after the baby is born. Surgery during ...
Breast Cancer Screening (PDQ®): Screening - Health Professional Information [NCI] - Appendix of Randomized Controlled Trials
Health Insurance Plan, United States 1963 [1,2]Age at entry: 40 to 64 years.Randomization: Individual, but with significant imbalances in the distribution of women between assigned arms, as evidenced by menopausal status (P < .0001) and education (P = .05). Sample size: 30,000 to 31,092 in study group and 30,565 to 30,765 in control group. Consistency of reports: Variation in sample size reports. Intervention: Annual two-view mammography (MMG) and CBE for 3 years. Control: Usual care. Compliance: Nonattenders to first screening (35% of the screened population) were not reinvited.Contamination: Screening MMG was not available outside the trial, but frequency of CBE performance among control women is unknown.Cause of death attribution: Women who died of breast cancer that had been diagnosed before entry into the study were excluded from the comparison between the screening and control groups. However, these exclusions were determined differently
Breast Cancer Treatment and Pregnancy (PDQ®): Treatment - Health Professional Information [NCI] - Other Considerations for Pregnancy and Breast Cancer
Lactation Suppression of lactation does not improve prognosis. If surgery is planned,however,lactation should be suppressed to decrease the size and vascularity of the breasts. If chemotherapy is to be given,lactation should also be suppressed because many antineoplastics (specifically cyclophosphamide and methotrexate),when given systemically,may occur in high levels in breast milk and ...