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    Gene Therapy: The Future Is Now

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    WebMD Health News

    April 27, 2000 -- For the longest time, there has been talk about how gene therapy holds great promise for the future of medicine. Well, it looks like the future is now. Gene therapy is finally showing signs of being a promise kept, thanks to some French researchers.

    In the April 28 issue of Science, the researchers detail their success in using gene therapy to treat children whose faulty immune systems otherwise would have forced them to spend their lives in a sterile "bubble." In the wake of the death last fall of an Arizona teen-ager during a University of Pennsylvania gene-therapy experiment, the latest advance is leading to renewed hope for the technique.

    But what exactly is that hope? A drug-free, permanent solution for many types of disease, it would seem.

    Drugs work from the outside in, and must be continuously re-administered if the disease is chronic. Gene therapy works from the inside, and should keep working indefinitely. A key struggle for researchers is finding the right gene to address the disease in question, and making sure that gene is delivered to the right place in the body.

    Which brings us to the recent success. The disease the French researchers may have cured is well known, but rare. Does gene therapy hold promise for the big daddies of disease: cancer, diabetes, heart disease? You bet, and then some.

    W. French Anderson, MD, is credited with performing the first gene treatment in 1990 (for the same type of disease treated by the French researchers). He tells WebMD that the recent gene therapy successes are analogous to man's first landing on the moon.

    "We started off with a big burst of enthusiasm, just like [what] happened when [President] Kennedy made the announcement we're going to beat the Russians to the moon. And then there's all this high hope, and everybody rushes out to watch the rockets go up, and they blow up," Anderson says, making the comparison to the death in the Pennsylvania trial. "Things got really bad for a while, then all the little parts started working. ... We made it." Anderson, who wrote a commentary about the French research in Science, is director of the gene therapy laboratories at the University of Southern California in Los Angeles.

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