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Breast Cancer Health Center

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Femara Prevents Breast Cancer Recurrence

Drug Picks Up Where Tamoxifen Leaves Off in Reducing Cancer Risks
WebMD Health News

Oct. 9, 2003 -- Women who survived their first battle with breast cancer may now have a powerful new tool to prevent the dreaded disease from coming back, even years after other treatments have lost their edge.

A major new study announced today shows that the drug Femara picks up where the breast cancer drug tamoxifen leaves off and cuts the risk of breast cancer recurrence nearly in half among postmenopausal women with hormone-dependent breast cancers.

The benefits of this therapy were so significant that researchers stopped their study short in order to make the drug available to more women. The results of the study were announced today at a news conference in Toronto and released in advance of the scheduled Nov. 6 publication date in TheNew England Journal of Medicine.

About two-thirds of all breast cancers depend on hormones such as estrogen to grow, and researchers say hundreds of thousands of postmenopausal women worldwide who have had estrogen-sensitive breast cancers may benefit from this new treatment option.

Femara Fights Breast Cancer in the Long Run

Tamoxifen is a commonly used drug for preventing breast cancer recurrence among postmenopausal women who had hormone-dependent breast cancers. It works by binding to estrogen receptors and depriving breast cancer cells of the estrogen they need.

But the benefits of tamoxifen therapy taper off after five years. After that, there has been little doctors could do to reduce the risk of cancer recurrence among these women.

"For many years, we have lacked the tools to address the ongoing substantial risk of breast cancer after five years," says researcher Paul Goss, MD, PhD, of Princess Margaret Hospital in Toronto, who spoke at the briefing.

"What is unrecognized by many doctors and patients is that over 50% of recurrences that occur from breast cancer unfortunately occur over the long term, beyond five years after diagnosis," says Goss. "It becomes a dark cloud that hangs over patients and their families for many years after the primary diagnosis."

The study involved 5,187 postmenopausal women who had completed an average of five years of tamoxifen therapy and compared the effects of a once-a-day Femara pill vs. placebo in preventing breast cancer recurrence.

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