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    Celebrex: Lower Breast Cancer Risk?

    But Heart Safety Questions Remain
    By
    WebMD Health News
    Reviewed by Louise Chang, MD

    Jan. 30, 2006 -- There is more evidence that the same embattled prescription pain relievers suspected of raising the risk of heart attack and stroke may also help prevent certain cancers.

    In a newly published study, women who took the drugs Celebrex or Vioxx every day for at least two years were found to have a significant reduction in breast cancer risk, compared with nonusers. Celebrex and Vioxx are part of a class of drugs called Cox-2 inhibitors.

    Daily use of other anti-inflammatory pain relievers was also found to be protective, but the Celebrex and Vioxx users had the largest reduction in cancer risk.

    Troubled Past

    Vioxx was taken off the market in the fall of 2004 after research showed that long-term use increased the risk of heart attacks and strokes. Celebrex remains on the market, but questions remain about its cardiovascular safety.

    It was reported last month that Celebrex manufacturer Pfizer will finance a $100 million study in hopes of proving that the drug is safe for use by arthritis patients who are also at risk for heart attacks and strokes.

    Anti-inflammatory medications work by suppressing inflammation, and inflammation is increasingly believed to play a major role in the development of certain cancers. For this reason, the Cox-2s have been studied as potential anticancer agents.

    In addition to raising concerns about its heart risks, the large study that led to the withdrawal of Vioxx also suggested that the drug protects against colorectal cancer by preventing the formation of precancerous colon polyps.

    71% Reduced Breast Cancer Risk

    In the new study, researchers examined whether past use of Cox-2 inhibitors or other nonsteroidal anti-inflammatory drugs (NSAIDs) was a factor in breast cancer risk.

    The study involved 323 women with breast cancer and compared them with 649 women with no history of cancer matched for age, race, and place of residence. All the participants were questioned to determine their risk factors for breast cancer and their use of Cox-2 inhibitors and other NSAIDs. The women with breast cancer were found to have classic risk factors for breast cancer, including a family history of breast or ovarian cancer, smoking, never being pregnant, and taking or have taken estrogen replacement therapy after menopause.

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