3 Breast Cancer Gene Tests 'Promising'
Breast Cancer Gene Tests Help Check Recurrence Risk and Treatment Options
Feb. 4, 2008 -- Three breast cancer gene tests may
provide insights on recurrence risk and chemotherapy treatment.
So say Johns Hopkins University's Luigi Marchionni, MD, PhD, and
They reviewed data on three breast cancer gene tests that are
already on the market -- Oncotype
MammaPrint, and H/I -- which check activity of various breast
Oncotype DX screens 21 genes, MammaPrint screens 70 genes, and H/I screens
two genes. The tests aren't marketed for all women; they're geared to breast
The bottom line: The tests provide information, but it's not yet clear how
to put that information in context or into practice.
"Although these tests show great promise to improve predictions of
prognosis and treatment benefit for early-stage breast cancer, more needs to be
learned about the extent of that improvement, in whom they affect, and how they
are best incorporated into decision-making about current breast cancer treatment,"
Marchionni's team writes.
The review appears online today in the Annals of Internal