Aspirin-Breast Cancer Study Doesn't Prove Cause and Effect
Although provocative, the study only shows an association and does not prove cause and effect, says Steven Isakoff, MD, PhD, a breastcancer specialist at Massachusetts General Hospital Cancer Center in Boston.
Also, long-term use of aspirin carries the risk of serious side effects, such as stomach bleeding and ulcers, he tells WebMD.
Still, if the findings can be confirmed in a large study in which half the women are given aspirin and half aren't and all are followed over time to see how many in each group develop breast cancer, the painkiller could have a huge impact, particularly in underdeveloped nations, Isakoff says.
"As a public health measure, aspirin is cheap and easy," he says.
Previous Studies on Aspirin and Breast Cancer a Mixed Bag
Makubate says the previous studies looking at aspirin use in breast cancer have had conflicting results.
Laboratory work at his institution suggests aspirin could have an effect on breast cancer by blocking the Cox-2 enzyme that promotes inflammation and cell growth.
So Makubate and colleagues combed the medical records of British women aged 25 and older who were cancer-free in 1998. By the end of 2003, 1,420 (1.2%) developed breast cancer.
Prescription records showed one in five women took aspirin during the study period.