Sept. 12, 2012 (San Francisco) -- Tests often performed to look for cancer spread in women with early-stage breast cancer are generally unnecessary, new research suggests.
Analysis of pooled data from eight published studies involving about 1,700 women with breast cancer shows that bone scans, liver ultrasounds, and chest X-rays very rarely detect the spread of cancer in newly diagnosed patients without symptoms.
"The findings reinforce the message we sent out to members regarding the lack of utility of almost any X-ray in low-risk patients -- that is, those with Stage 1 or Stage II breast cancer. Additionally, we showed the cost-effectiveness of ordering bone scans, PET, and CT imaging is so low that they should not be done," says American Society of Clinical Oncology (ASCO) spokesman Andrew Seidman, MD. He is a medical oncologist at Memorial Sloan-Kettering Cancer Center in New York City.
"If doctors would heed the recommendations, we would save an enormous amount of money and spare patients from unnecessary invasive procedures, overtreatment, unnecessary radiation exposure, and misdiagnosis," he says.
The problem: Old habits die hard, particularly among doctors who are afraid of missing potentially treatable cancer spread outside the breast area if they don't order the tests, Seidman says. He was not involved with the study, presented at a news briefing in advance of the 2012 Breast Cancer Symposium, which starts Thursday.
An estimated 226,870 new cases of invasive breast cancer are expected to occur in women and 2,190 cases in men in the U.S. in 2012. An additional 63,300 cases of in situ (non-invasive) breast cancers are expected to occur in U.S. women, totaling more than 290,000 new cases. Non-invasive breast cancer means the cancer has remained in the milk ducts or lobules of the breast, whereas invasive cancer means it has grown into the healthy breast tissue.
In Europe and Canada, it is common for newly diagnosed patients to get a bone scan, a liverultrasound, and chest X-ray to look for signs of cancer spread, says researcher Stuart-Allison Moffat Staley, MPH, a medical student at the University of North Carolina School of Medicine.