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    Breast Cancer Radiation May Affect Heart Later On

    But expert says cancer-fighting benefits outweigh heart-disease risks

    continued...

    In recent years, Taylor said, improvements in radiation machines have made it possible to deliver radiation more accurately so the heart receives less exposure.

    Taylor evaluated each woman's average dose of radiation to the heart. The overall average was 4.9 units, or grays. Women with cancer in the left breast -- which is closer to the heart -- averaged more heart exposure (6.6 grays). Today, Taylor said, the average overall ranges from 2 grays to 10 grays.

    The rate of heart problems increased by 7.4 percent per gray. No starting threshold was found.

    The risk started within five years after treatment and persisted into the third decade.

    The proportional increase was similar in women with and without heart disease risk factors (such as high blood pressures) at the start. Those with pre-existing risk factors, however, had greater absolute increases in risk.

    To put the finding in perspective, for a 50-year-old woman with no pre-existing heart disease risk factors, a dose to the heart of 3 grays would increase the risk of death from ischemic heart disease before age 80 from 1.9 percent to 2.4 percent, Taylor said.

    Doctors should identify women with pre-existing heart disease risk factors and those with a small distance between heart and breast and give the radiation in a way that minimizes heart exposure, Taylor said.

    Editorial author Moslehi, who also is an instructor of medicine at Harvard Medical School, said the study results are important, but not entirely reassuring. "It suggests that women should worry about heart disease risk after radiation therapy," he said. The new findings "may be just the tip of the iceberg," he said.

    Taylor's team did not look at all types of heart problems, Moslehi said. Radiation therapy has been linked with other cardiac problems, including heart rhythm issues and valve problems.

    In addition, he said, some chemotherapy has been linked with heart risks.

    Until more research is in, Moslehi said women should be sure their primary-care doctor knows if they had radiation therapy for breast cancer. The doctor should also evaluate other cardiac risk factors, such as high blood pressure and cholesterol, he added.

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