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    Fear Prompts Some Preventive Mastectomies

    Many young women with breast cancer overestimated risk of recurrence in opposite breast

    WebMD News from HealthDay

    By Kathleen Doheny

    HealthDay Reporter

    MONDAY, Sept. 16 (HealthDay News) -- Young women with breast cancer tend to overestimate their risk for getting cancer in the opposite, healthy breast -- sometimes driving them to have that breast removed, according to new research.

    Researchers polled 123 young women two years after they chose double mastectomy for breast cancer at age 40 and younger, asking how they made the decision to have the opposite breast removed and how they estimated the cancer risk in the healthy breast.

    "Most women who were considered average risk actually overestimated their risk of having contralateral [opposite breast] breast cancer," said study researcher Shoshana Rosenberg, a research fellow at Harvard School of Public Health and Dana-Farber Cancer Institute.

    Despite evidence that having the procedure -- called contralateral prophylactic mastectomy -- does not improve survival rates, growing numbers of women treated for early stage breast cancer decide to have it, the study authors said. While about 6 percent of women with early stage cancers had the procedure in the 1990s, now up to one-fourth do.

    Rosenberg and her colleagues wanted to look more closely at the patients' decision-making process. The research is published in the Sept. 17 issue of Annals of Internal Medicine.

    In the survey, 98 percent of women who opted for contralateral prophylactic mastectomy said they wanted to avoid getting cancer in the opposite breast and 94 percent said they wanted to improve survival, although only 18 percent believed that the procedure actually improved survival.

    About one-quarter of the women were genetically at higher risk of cancer, due to having a BRCA gene mutation. Of participants who did not have the gene mutation, patients estimated that 10 percent would get cancer in the opposite breast within five years without the preventive surgery, although the actual risk is about 2 percent to 4 percent over the five years, according to Rosenberg.

    "Risk perception is very complex," Rosenberg said. "It could be that their doctor is not communicating it effectively." In addition, this is a very anxiety-provoking time period. "There are lots of decisions to make, and concerns about recurrence," she noted.

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