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Breast Cancer Health Center

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Obesity May Raise Breast Cancer Death Risk for Some

Study found younger, obese patients with estrogen receptor-positive disease were more likely to die

WebMD News from HealthDay

By Kathleen Doheny

HealthDay Reporter

THURSDAY, May 15, 2014 (HealthDay News) -- A new study suggests that obesity may raise the risk of dying from early stage breast cancer for some women.

Obese women who had not yet gone through menopause and who had a form of the disease known as estrogen receptor-positive (ER-positive) were more likely than others to die of the disease, according to an analysis of the results of 70 clinical trials.

Those women were 34 percent more likely to die of their breast cancer, the researchers found. However, obesity had little effect on breast cancer death risk among postmenopausal women with ER-positive disease or among women with ER-negative breast cancer.

"It is a finding which is the exact opposite of what we have expected," said study author Hongchao Pan, a senior research fellow at the University of Oxford in England. Other studies have found that being overweight was somewhat protective against breast cancer before menopause.

The finding was released Wednesday, in advance of the American Society of Clinical Oncology annual meeting in Chicago. The review will be formally presented at the meeting on May 31.

Almost two of three breast cancers are hormone receptor-positive, either estrogen receptor-positive or progesterone receptor-positive, according to the American Cancer Society.

The new findings suggest that obesity, thought by some researchers to be protective before menopause, may be risky at any age. To date, ''studies have provided convincing evidence that obesity is associated with an increased risk of developing breast cancer after menopause, but not before the menopause," Pan said.

"Among women who develop breast cancer, obesity is reportedly associated with somewhat worse prognosis," he said. However, experts have thought that the link could depend on the form of breast cancer and whether the tumor is estrogen receptor-positive. Studies on this, as well as the effect of menopausal status, have been inconclusive, Pan said.

So Pan's team evaluated the risk of breast cancer death in more than 80,000 women with early breast cancer who had been enrolled in 70 clinical trials.

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