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Breast Cancer Health Center

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Double Mastectomy Doesn't Improve Survival: Study

But many more women in U.S. are choosing the radical procedure

WebMD News from HealthDay

By Kathleen Doheny

HealthDay Reporter

TUESDAY, Sept. 2, 2014 (HealthDay News) -- More U.S. women with early stage breast cancer are choosing to have both breasts removed as a precautionary step, although the double mastectomy provides no apparent survival advantage, researchers say.

Death rates are similar for women who have both breasts taken off and those who opt for breast-conserving surgery known as lumpectomy, according to their new study.

"We found no lower death rates among women who had bilateral mastectomy compared to women who had breast-conserving surgery with radiation," said study researcher Scarlett Gomez, a research scientist at the Cancer Prevention Institute of California.

The results are important for women at average risk of breast cancer, Gomez and other experts said.

Tracking health data on more than 189,000 breast cancer patients in California, researchers found that the number of women opting for double -- or bilateral -- mastectomy jumped from 2 percent in 1998 to 12.3 percent in 2011.

One-third of women younger than 40 opted for a double mastectomy in 2011, compared to less than 4 percent at the study's start, the researchers said.

The study, published Sept. 3 in the Journal of the American Medical Association, followed most of the patients for at least seven years.

The preventive, or prophylactic, double mastectomy has been in the spotlight recently. In 2013, actress Angelina Jolie announced she had had a preventive double mastectomy because of a strong family history of breast and ovarian cancer. She'd also tested positive for the genetic mutation BRCA1, which raises breast cancer risk.

Gomez said her team realized the proportion of women opting for double mastectomy had surged in recent years and wanted to see what effect the more extensive surgery had on survival. The radical surgery is associated with higher costs, longer recovery and greater risk of complications.

Using information from a California cancer registry, they looked at survival after double mastectomy, breast-conserving therapy (lumpectomy) with radiation, and single mastectomy (removal of one breast) in women who had early cancer in one breast. The registry didn't include genetic information that might have indicated raised breast cancer risk.

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