Table 1 describes the histologic classification of breast cancer based on tumor location. Infiltrating or invasive ductal cancer is the most common breast cancer histologic type and comprises 70% to 80% of all cases.
Table 1. Tumor Location and Related Histologic Subtype
NOS = not otherwise specified.
Intraductal (in situ)
Invasive with predominant component
Medullary with lymphocytic infiltrate
Invasive with predominantin situ component
Paget disease, NOS
Paget disease with intraductal carcinoma
Paget disease with invasive ductal carcinoma
The following tumor subtypes occur in the breast but are not considered typical breast cancers:
Breast. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 347-76.
Yeatman TJ, Cantor AB, Smith TJ, et al.: Tumor biology of infiltrating lobular carcinoma. Implications for management. Ann Surg 222 (4): 549-59; discussion 559-61, 1995.
Chaney AW, Pollack A, McNeese MD, et al.: Primary treatment of cystosarcoma phyllodes of the breast. Cancer 89 (7): 1502-11, 2000.
Carter BA, Page DL: Phyllodes tumor of the breast: local recurrence versus metastatic capacity. Hum Pathol 35 (9): 1051-2, 2004.
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