How far have we come in women’s cancer? Keeping up with the latest treatment trends and studies about cancer of the breast, ovary, uterus, and cervix can be daunting. New studies come out seemingly every week with hot-off-the-press -- and often contradictory -- results. Mammograms? They’re either the key to prevention or misleading at best. And what’s the final word on hormone replacement therapy? Does it prevent or cause cancer? Experts have even recently challenged the value of sticking to a low-fat...
Breast-conserving surgery to remove only the cancer and some surrounding breast tissue, followed by lymph node dissection and radiation therapy.
Modified radical mastectomy with or without breast reconstruction surgery.
Sentinel lymph node biopsy followed by surgery.
Adjuvant therapy (treatment given after surgery to lower the risk that cancer will come back) may include the following:
Radiation therapy to the lymph nodes near the breast and to the chest wall after a modified radical mastectomy.
Chemotherapy with or without hormone therapy.
Monoclonal antibody therapy with trastuzumab combined with chemotherapy.
A clinical trial of new targeted therapies.
Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage I breast cancer, stage II breast cancer, stage IIIA breast cancer and stage IIIC breast cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.
Stage IIIB, Inoperable Stage IIIC, Stage IV, and Metastatic Breast Cancer
Stage IIIB and inoperable stage IIIC breast cancer
Treatment of stage IIIB and inoperable stage IIIC breast cancer may include the following:
Chemotherapy followed by surgery (breast-conserving surgery or total mastectomy), with lymph node dissection followed by radiation therapy. Additional therapy (chemotherapy, hormone therapy, or both) may be given.
Clinical trials testing new anticancer drugs, new drug combinations, and new ways of giving treatment.
Stage IV and metastatic breast cancer
Treatment of stage IV or metastatic breast cancer may include the following:
Hormone therapy and/or chemotherapy with or without trastuzumab.
Monoclonal antibody therapy with trastuzumab and pertuzumab combined with chemotherapy.
Antibody-drug conjugate therapy with ado-trastuzumab emtansine.
Tyrosine kinase inhibitor therapy with lapatinib combined with capecitabine.
Radiation therapy and/or surgery for relief of pain and other symptoms.
Bisphosphonate drugs to reduce bone disease and pain when cancer has spread to the bone.
Clinical trials testing new chemotherapy and/or hormone therapy.
Clinical trials of new combinations of treatments, including targeted therapy, hormone therapy, and chemotherapy.
Clinical trials testing other treatments, including high-dose chemotherapy with stem cell transplant.
Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage IIIB breast cancer, stage IIIC breast cancer and stage IV breast cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.
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Institute via the Internet web site at http://
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WebMD Public Information from the National Cancer Institute
September 04, 2014
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