Skip to content

Breast Cancer Health Center

Font Size

Changes to This Summary (03 / 04 / 2013)

    The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

    Introduction

    Recommended Related to Breast Cancer

    Me and the Girls: Tammy Joyner

    WebMD senior writer Miranda Hitti interviewed breast cancer survivors as part of a series for Breast Cancer Awareness Month. The series, called “Me & the Girls,” explores the personal stories of these women after they were diagnosed with breast cancer. Breast cancer survivor Tammy Joyner, 49, lives in the Atlanta area. When Joyner was 45 years old, she went to see her gynecologist after noticing some breast changes -- aches and soreness that she wasn't used to. "I said, 'Something's...

    Read the Me and the Girls: Tammy Joyner article > >

    Updated statistics with estimated new cases and deaths of breast cancer and ovarian cancer for 2013 (cited American Cancer Society as reference 1).

    Added Figure 1, Classic BRCA1 Pedigree.

    Added Figure 2, Classic BRCA2 Pedigree.

    Revised text to state that studies examining the impact of radiation exposure, including, but not limited to, mammography, in BRCA1 and BRCA2 mutation carriers have had conflicting results (cited Goldfrank et al., Gronwald et al., and Pijpe et al. as references 44, 45, and 46, respectively). Also added text to state that a large European study showed a dose-response relationship of increased risk with total radiation exposure, but this was primarily driven by nonmammographic radiation exposure before age 20 years.

    High-Penetrance Breast and/or Ovarian Cancer Susceptibility Genes

    Added text to state that the inclusion of breast tumor markers, such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, has been shown to improve the performance of BRCAPRO and the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (cited Biswas et al., Mavaddat et al., and Tai et al. as references 104, 105, and 106, respectively).

    Added Liu et al. as reference 252.

    Added text to state that two studies failed to find convincing evidence of an association between ionizing radiation exposure and breast cancer risk in BRCA1 and BRCA2 mutation carriers (cited Narod et al. and Goldfrank et al. as references 282 and 283, respectively). Also added text about two large international studies that found evidence of an increased risk due to chest x-rays (cited Andrieu et al. as reference 284) or estimates of total exposure to diagnostic radiation (cited Pijpe et al. as reference 285).

    Added text about a study that suggested that the most cost-effective screening strategy in BRCA1 and BRCA2 mutation carriers may be annual magnetic resonance imaging (MRI) beginning at age 25 years, with alternating MRI and digital mammography beginning at age 30 years (cited Lowry et al. as reference 287); the National Comprehensive Cancer Network currently recommends annual mammography and MRI screening beginning at age 25 years.

      1|2

      Today on WebMD

      Breast Cancer Overview
      From self-exams and biopsies to reconstruction, we’ve got you covered.
      Dealing with breast cancer
      Get answers to your questions.
       
      woman having mammogram
      Experts don’t agree on all fronts, but you can be your own advocate.
      woman undergoing breast cancer test
      Many women worry. But the truth? Most abnormalities aren’t breast cancer.
       
      Breast Cancer Treatments Improving
      VIDEO
      Resolved To Quit Smoking
      SLIDESHOW
       
      Woman getting mammogram
      Article
      Screening Tests for Women
      SLIDESHOW
       
      ovarian cancer overview slideshow
      SLIDESHOW
      serious woman
      Article
       
      what is your cancer risk
      HEALTH CHECK
      10 Ways to Revitalize Slideshow
      SLIDESHOW
       

      WebMD Special Sections