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Breast Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Stage I, II, IIIA, and Operable IIIC Breast Cancer

Table 8. Adjuvant Systemic Treatment Options for Women With Axillary Node-Negative Breast Cancer

Patient GroupLow RiskIntermediate RiskHigh Risk
AI = aromatase inhibitor; ER = estrogen receptor; GnRH = gonadotropin-releasing hormone; PR = progesterone receptor
a Note: This treatment option is under clinical evaluation.
Premenopausal, ER-positive or PR-positiveNone or tamoxifenTamoxifen plus chemotherapy, tamoxifen alone, ovarian ablation, GnRH analogaChemotherapy plus tamoxifen, chemotherapy plus ablation or GnRH analog*, chemotherapy plus tamoxifen plus ovarian ablation or GnRH*, or ovarian ablation alone or with tamoxifen or GnRH alone or with tamoxifen
Premenopausal, ER-negative or PR-negativeChemotherapy
Postmenopausal, ER-positive or PR-positiveNone or upfront AI or tamoxifen followed by AIUpfront AI or tamoxifen followed by AI +/- chemotherapyUpfront AI or tamoxifen followed by AI +/- chemotherapy
Postmenopausal, ER-negative or PR-negativeChemotherapy

Table 9. Treatment Options for Women With Axillary Node-Positive Breast Cancer

Patient GroupTreatments
AI= aromatase inhibitors; ER = estrogen receptor; GnRH = gonadotropin-releasing hormone; PR = progesterone receptor
a Note: This treatment option is under clinical evaluation.
Premenopausal, ER-positive or PR-positiveChemotherapy plus tamoxifen, chemotherapy plus ovarian ablation/GnRH analog, chemotherapy plus tamoxifen plus ovarian ablation/GnRH analoga, ovarian ablation alone or with tamoxifen or GnRH alone or with tamoxifen
Premenopausal, ER-negative or PR-negativeChemotherapy
Postmenopausal, ER-positive or PR-positiveUpfront AI or tamoxifen followed by AI plus chemotherapy, upfront AI or tamoxifen followed by AI alone
Postmenopausal, ER-negative or PR-negativeChemotherapy

Current Clinical Trials

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage I breast cancer, stage II breast cancer, stage IIIA breast cancer and stage IIIC breast cancer. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.

General information about clinical trials is also available from the NCI Web site.

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