Chemotherapy is a chemical, or group of chemicals, designed to stop the growth of cancer cells. Chemotherapy drugs may be given intravenously, orally, or as a combination of the two. There are many chemotherapy drugs used to treat breast cancer.
When breast cancer is limited to the breast or lymph nodes, chemotherapy may be given after a lumpectomy or mastectomy. This is done to help reduce the chance of breast cancer coming back.
Triple-negative breast cancer (TNBC) is defined as the absence of staining for estrogen receptor, progesterone receptor, and HER2/neu. TNBC is insensitive to some of the most effective therapies available for breast cancer treatment including HER2-directed therapy such as trastuzumab and endocrine therapies such as tamoxifen or the aromatase inhibitors. Combination cytotoxic chemotherapy administered in a dose-dense or metronomic schedule remains the standard therapy for early-stage TNBC. A prospective...
If the breast tumor is large, chemotherapy is sometimes given before surgery in order to shrink the tumor so it can be removed more easily or so that a lumpectomy can be performed instead of a mastectomy.
Chemotherapy may also be given as the main treatment for women whose cancer has spread to other parts of the body outside of the breast and lymph nodes.