Bladder Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Stage III Bladder Cancer
Radical cystectomy with or without pelvic lymph node dissection.
Neoadjuvant platinum-based combination chemotherapy followed by radical cystectomy.
External-beam radiation therapy (EBRT) with or without concurrent chemotherapy.[3,4,5,6,12,13,14,18]
EBRT with interstitial implantation of radioisotopes.
Segmental cystectomy (in highly selected cases).
Current Clinical Trials
Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage III bladder cancer. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.
General information about clinical trials is also available from the NCI Web site.
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Neoadjuvant cisplatin, methotrexate, and vinblastine chemotherapy for muscle-invasive bladder cancer: a randomised controlled trial. International collaboration of trialists. Lancet 354 (9178): 533-40, 1999.
Advanced Bladder Cancer Meta-analysis Collaboration.: Neoadjuvant chemotherapy in invasive bladder cancer: a systematic review and meta-analysis. Lancet 361 (9373): 1927-34, 2003.
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