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Stage 0 Bladder Cancer

    Stage 0 bladder cancer is defined by the following TNM classifications:

    • Ta, N0, M0
    • Tis, N0, M0

    Patients with stage 0 bladder tumors can be cured by a variety of treatments, even though the tendency for new tumor formation is high. In a series of patients with Ta or T1 tumors, who were followed for a minimum of 20 years or until death, the risk of bladder cancer recurrence following initial resection was 80%.[1] Patients at greatest risk of recurrent disease are those whose tumors are large, poorly differentiated, multiple, or associated with nuclear p53 overexpression. In addition, patients with carcinomain situ (Tis) or dysplasia of grossly uninvolved bladder epithelium are at greater risk of recurrence and progression.[1,2,3]

    Recommended Related to Bladder Cancer

    Understanding Bladder Cancer -- Prevention

    To prevent bladder cancer, your best bet is to avoid possible carcinogens, or cancer-causing substances. For starters, don't smoke. Eat smoked or cured meats only occasionally and prepare fresh rather than processed foods. Research also suggests that there is a reduced incidence of bladder cancer among people with adequate vitamin B-6, beta-carotene, and selenium in their diets. If you work around carcinogenic chemicals, follow safety guidelines to avoid undue exposure. And if you feel you may be...

    Read the Understanding Bladder Cancer -- Prevention article > >

    Transurethral resection (TUR) and fulguration are the most common and conservative forms of management. Careful surveillance of subsequent bladder tumor progression is important. One retrospective series addressed the value of performing a second TUR within 2 to 6 weeks of the first.[4][Level of evidence: 3iiDiv] A second TUR performed on 38 patients with Tis or Ta disease found that nine patients (24%) had lamina propria invasion (T1) and three patients (8%) had muscle invasion (T2). Such information may change the definitive management options in these individuals.

    Patients who require more aggressive forms of treatment are those with extensive multifocal recurrent disease and/or other unfavorable prognostic features. Segmental cystectomy is applicable to only a small minority of patients because of the tendency of bladder carcinoma to involve multiple regions of the bladder mucosa and to occur in areas that cannot be segmentally resected.

    Intravesical therapy with thiotepa, mitomycin, doxorubicin, or bacillus Calmette-Guérin (BCG) is most often used in patients with multiple tumors or recurrent tumors or as a prophylactic measure in high-risk patients after TUR. Administration of intravesical BCG plus subcutaneous BCG following TUR was compared with TUR alone in patients with Ta and T1 lesions. Treatment with BCG delayed progression to muscle-invasive and/or metastatic disease, improved bladder preservation, and decreased the risk of death from bladder cancer.[5,6]

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