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Cellular Classification of Urethral Cancer

    In an analysis of Surveillance, Epidemiology, and End Results data from 1973 to 2002, the most common histologic types of urethral cancer were:[1]

    • Transitional cell (55%).
    • Squamous cell (21.5%).
    • Adenocarcinoma (16.4%).

    Other cell types, such as melanoma, were extremely rare.[1]

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    Understanding Bladder Cancer -- the Basics

    The bladder is a pouch in the urinary tract that stores urine after it is produced by the kidneys. The bladder is lined with specialized cells called transitional cells. Bladder cancer often arises from these transitional cells. The cancer spreads by penetrating bladder muscle, infiltrating surrounding fat and tissue, and -- if untreated -- spreads to lymph nodes and other organs, such as the liver, lungs, or bones. The earlier the cancer is diagnosed, the more limited it will likely be and...

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    The female urethra is lined by transitional cell mucosa proximally and stratified squamous cells distally. Therefore, transitional cell carcinoma is most common in the proximal urethra and squamous cell carcinoma predominates in the distal urethra. Adenocarcinoma may occur in both locations and arises from metaplasia of the numerous periurethral glands.

    The male urethra is lined by transitional cells in its prostatic and membranous portion and stratified columnar epithelium to stratified squamous epithelium in the bulbous and penile portions. The submucosa of the urethra contains numerous glands. Therefore, urethral cancer in the male can manifest the histological characteristics of transitional cell carcinoma, squamous cell carcinoma, or adenocarcinoma.

    Except for the prostatic urethra, where transitional cell carcinoma is most common, squamous cell carcinoma is the predominant histology of urethral neoplasms. Since transitional cell carcinoma of the prostatic urethra may be associated with transitional cell carcinoma of the bladder and/or transitional cell carcinoma arising in prostatic ducts, it is often treated similarly to these primaries and should be separated from the more distal carcinomas of the urethra.

    References:

    1. Swartz MA, Porter MP, Lin DW, et al.: Incidence of primary urethral carcinoma in the United States. Urology 68 (6): 1164-8, 2006.

      WebMD Public Information from the National Cancer Institute

      Last Updated: February 25, 2014
      This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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