Pineal Parenchymal Tumors
Pineocytoma (World Health Organization [WHO] grade II),pineoblastoma (WHO grade IV),and pineal parenchymal tumors of intermediate differentiation are diverse tumors that require special consideration. Pineocytomas are slow growing and carry variable prognoses for cure. Pineoblastomas are more rapidly growing and have worse prognoses. Pineal parenchymal tumors of intermediate differentiation ...
Note: Separate PDQ summaries on Childhood Brain Stem Glioma Treatment; Childhood Cerebellar Astrocytoma Treatment; Childhood Cerebral Astrocytoma/Malignant Glioma Treatment; Childhood Medulloblastoma Treatment; Childhood Supratentorial Primitive Neuroectodermal Tumors and PineoblastomaTreatment; and Childhood Visual Pathway and Hypothalamic Glioma Treatment are also available. This cancer ...
Treatment of Recurrent Childhood Brain and Spinal Cord Tumors
Recurrence is not uncommon in both low-grade and malignant childhood brain tumors and may occur many years after initial treatment.
ABOUT PDQ PDQ® - NCI's Comprehensive Cancer Database. Full description of the NCI PDQ database. ADDITIONAL PDQ SUMMARIES PDQ® Cancer Information Summaries: Adult Treatment Treatment options for adult cancers. PDQ® Cancer Information Summaries: Pediatric Treatment Treatment options for childhood cancers. PDQ® Cancer Information Summaries: Supportive Care Side effects of cancer treatment,...
Brain Stem Gliomas
Brain stem gliomas have relatively poor prognoses that correlate with histology (when biopsies are performed),location,and extent of tumor. The overall median survival time of patients in studies has been 44 to 74 weeks.[ 1,2,3,4,5 ] The best results have been attained with hyperfractionated radiation therapy.[ 5 ] STANDARD TREATMENT OPTIONS: Radiation therapy.[ 1,2,3,4,5,6 ] ...
Nonfunctioning Pituitary Tumors
The selection of treatment for patients with nonfunctioning (endocrine-inactive) tumors will depend on tumor size,the progressive course of the disease,and anatomical structures affected by the tumor extension. The majority of patients present with suprasellar extension and visual field deficits. In addition,many have hormone deficits prior to treatment. Surgical management is typically ...
Grade I and II ependymal tumors Ependymomas (World Health Organization [WHO] grade II) and WHO grade I ependymal tumors,i.e.,subependymoma and myxopapillary ependymomas,are often curable. (Refer to the Ependymal tumors section in the classification section of this summary for more information.) STANDARD TREATMENT OPTIONS: Surgery alone if the tumor is totally resectable. Surgery followed by ...
Recurrent Brain Tumors
STANDARD TREATMENT OPTIONS: Surgery alone or in conjunction with chemotherapy.[ 1,2,3 ] Radiation therapy if not previously used,alone or with chemotherapy. Interstitial radiation therapy.[ 4 ] Chemotherapy.[ 5 ] In a nonrandomized trial of patients with recurrent anaplastic oligodendrogliomas and oligoastrocytomas,significant response rates (i.e.,29% complete response and 29% partial ...
Some reports indicate that as many as 88% of pituitary carcinomas are endocrinologically active,and adrenocorticotrophin hormone-secreting tumors are the most common.[ 1 ] Treatments for patients with pituitary carcinomas are palliative with the mean survival time ranging from 2 years to 2.4 years,though several case reports of long-term survivors have been published.[ 2,3,4,5 ] STANDARD ...
This classification is based on the World Health Organization (WHO) classification of nervous system tumors.[ 1 ] The WHO approach incorporates and interrelates morphology,cytogenetics,molecular genetics,and immunologic markers in an attempt to construct a cellular classification that is universally applicable and prognostically valid. Earlier attempts to develop a TNM-based classification ...