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    Brain Cancer Health Center

    Medical Reference Related to Brain Cancer

    1. Childhood Brain Stem Glioma Treatment (PDQ®): Treatment - Patient Information [NCI] - Stages of Adult Brain Tumors

      There is no standard staging system for adult brain and spinal cord tumors.The extent or spread of cancer is usually described as stages. There is no standard staging system for brain and spinal cord tumors. Brain tumors that begin in the brain may spread to other parts of the brain and spinal cord, but they rarely spread to other parts of the body. Treatment of brain and spinal cord tumors is based the following:The type of cell in which the tumor began.Where the tumor formed in the brain or spinal cord.The amount of cancer left after surgery.The grade of the tumor.Treatment of brain tumors that have spread to the brain from other parts of the body is based on the number of tumors in the brain.Imaging tests may be repeated after surgery to help plan more treatment.Some of the tests and procedures used to diagnose a brain or spinal cord tumor may be repeated after treatment to find out how much tumor is left.

    2. Childhood Ependymoma Treatment (PDQ®): Treatment - Patient Information [NCI] - Treatment of Childhood High-Grade Astrocytomas

      Childhood low-grade astrocytomas may recur many years after initial treatment. Recurrent disease is usually at the primary tumor site, although multifocal or widely disseminated disease to other intracranial sites and to the spinal leptomeninges has been documented.[1,2] Most children whose low-grade fibrillary astrocytomas recur will harbor low-grade lesions; however, malignant transformation is possible.[3] Surveillance imaging will frequently identify asymptomatic recurrences.[4]At the time of recurrence, a complete evaluation to determine the extent of the relapse is indicated. Biopsy or surgical resection may be necessary for confirmation of relapse because other entities, such as secondary tumor and treatment-related brain necrosis, may be clinically indistinguishable from tumor recurrence. The need for surgical intervention must be individualized on the basis of the initial tumor type, the length of time between initial treatment and the reappearance of the mass lesion, and the

    3. Childhood Ependymoma Treatment (PDQ®): Treatment - Patient Information [NCI] - Treatment Option Overview

      There are different types of treatment for children with ependymoma. Different types of treatment are available for children with ependymoma. Some treatments are standard (the currently used treatment), and some are being tested in clinical trials. A treatment clinical trial is a research study meant to help improve current treatments or obtain information on new treatments for patients with cancer. When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment.Because cancer in children is rare, taking part in a clinical trial should be considered. Some clinical trials are open only to patients who have not started treatment. Children with ependymoma should have their treatment planned by a team of health care providers who are experts in treating childhood brain tumors.Treatment will be overseen by a pediatric oncologist, a doctor who specializes in treating children with cancer. The pediatric oncologist

    4. Childhood Ependymoma Treatment (PDQ®): Treatment - Patient Information [NCI] - nci_ncicdr0000062900-nci-header

      This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http://cancer.gov or call 1-800-4-CANCER.Adult Brain Tumors Treatment

    5. Childhood Brain Stem Glioma Treatment (PDQ®): Treatment - Patient Information [NCI] - Treatment Options for Childhood Brain Stem Glioma

      A link to a list of current clinical trials is included for each treatment section. For some types or stages of cancer, there may not be any trials listed. Check with your child's doctor for clinical trials that are not listed here but may be right for your child.Untreated Childhood Brain Stem GliomaUntreated childhood brain stem glioma is a tumor for which no treatment has been given. The child may have received drugs or treatment to relieve symptoms caused by the tumor.Standard treatment of diffuse intrinsic pontine glioma is usually radiation therapy.Some of the treatments being studied in clinical trials for diffuse intrinsic pontine glioma include the following:Radiation therapy with a radiosensitizer.Standard treatment of focal or low-grade glioma may include the following:Surgery with or without radiation therapy, which may be followed by adjuvant chemotherapy.Cerebrospinal fluid diversion followed by watchful waiting.Treatment of brain stem glioma in children with

    6. Childhood Ependymoma Treatment (PDQ®): Treatment - Patient Information [NCI] - Cellular Classification of Pituitary Tumors

      Pituitary adenomas can be classified according to staining affinities of the cell cytoplasm, size, endocrine activity, histologic characteristics, hormone production and contents, ultrastructural features, granularity of the cell cytoplasm, cellular composition, cytogenesis, and growth pattern.[1] Recent classifications, however, omit criteria based on tinctorial stains (i.e., acidophilic, basophilic, and chromophobic) because of the poor correlation between staining affinities of the cell cytoplasm and other pathological features of pituitary tumors, such as the type of hormone produced and cellular derivation.[1,2]A unifying pituitary adenoma classification incorporates the histological, immunocytochemical, and electron microscopic studies of the tumor cells, and stresses the importance of hormone production, cellular composition, and cytogenesis. This classification emphasizes the structure-function relationship and attempts to correlate morphologic features with secretory

    7. Childhood Ependymoma Treatment (PDQ®): Treatment - Patient Information [NCI] - nci_ncicdr0000062697-nci-header

      This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http://cancer.gov or call 1-800-4-CANCER.Adult Brain Tumors Treatment

    8. Childhood Ependymoma Treatment (PDQ®): Treatment - Patient Information [NCI] - Classification of Adult Brain Tumors

      This classification is based on the World Health Organization (WHO) classification of central nervous system (CNS) tumors.[1] The WHO approach incorporates and interrelates morphology, cytogenetics, molecular genetics, and immunologic markers in an attempt to construct a cellular classification that is universally applicable and prognostically valid. Earlier attempts to develop a TNM-based classification were dropped: tumor size (T) is less relevant than tumor histology and location, nodal status (N) does not apply because the brain and spinal cord have no lymphatics, and metastatic spread (M) rarely applies because most patients with CNS neoplasms do not live long enough to develop metastatic disease.[2]The WHO grading of CNS tumors establishes a malignancy scale based on histologic features of the tumor.[3] The histologic

    9. Childhood Ependymoma Treatment (PDQ®): Treatment - Patient Information [NCI] - General Information About Neuroblastoma

      Fortunately, cancer in children and adolescents is rare, although the overall incidence of childhood cancer has been slowly increasing since 1975.[1] Children and adolescents with cancer are usually referred to medical centers that have a multidisciplinary team of cancer specialists with experience treating the cancers that occur during childhood and adolescence. This multidisciplinary team approach incorporates the skills of the following health care professionals and others to ensure that children receive treatment, supportive care, and rehabilitation that will enable them to achieve optimal survival and quality of life: Primary care physician.Pediatric surgical subspecialists.Radiation oncologists.Pediatric medical oncologists/hematologists.Rehabilitation specialists.Pediatric nurse specialists.Social workers.(Refer to the PDQ summaries on Supportive and Palliative Care for specific information about supportive care for children and adolescents with cancer.)

    10. Childhood Ependymoma Treatment (PDQ®): Treatment - Patient Information [NCI] - Risks of Neuroblastoma Screening

      Screening tests have risks.Decisions about screening tests can be difficult. Not all screening tests are helpful and most have risks. Before having any screening test, you may want to discuss the test with your doctor. It is important to know the risks of the test and whether it has been proven to reduce the risk of dying from cancer.The risks of neuroblastoma screening include the following: Neuroblastoma may be overdiagnosed. When a screening test result leads to the diagnosis and treatment of a disease that may never have caused symptoms or become life-threatening, it is called overdiagnosis. For example, when a urine test result shows a higher than normal amount of homovanillic acid (HMA) or vanillyl mandelic acid (VMA), tests and treatments for neuroblastoma are likely to be done, but may not be needed. At this time, it is not possible to know which neuroblastomas found by a screening test will cause symptoms and which neuroblastomas will not. Diagnostic tests (such as biopsies)

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