Childhood Brain Stem Glioma Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Untreated Childhood Brain Stem Glioma
Diffuse Intrinsic Pontine GliomasConventional treatment for children with diffuse intrinsic pontine glioma (DIPG) is radiation therapy to involved areas. Such treatment will result in transient benefit for most patients, but over 90% of patients will die within 18 months of diagnosis. The conventional dose of radiation therapy ranges between 54 Gy and 60 Gy given locally to the primary tumor site in single daily fractions. Hyperfractionated (twice daily) radiation therapy techniques have been used to deliver a higher dose, and studies using doses as high as 78 Gy have been completed. Evidence demonstrates that these increased radiation therapy doses do not improve the duration or rate of survival for patients with DIPG whether given alone,[1,2] or in combination with chemotherapy. Hypofractionated radiation therapy does not improve survival.[Level of evidence: 2A] Studies evaluating the efficacy of various radiosensitizers as a means for enhancing the therapeutic
Childhood Brain Stem Glioma Treatment (PDQ®): Treatment - Patient Information [NCI] - General Information About Childhood Brain Stem Glioma
Childhood brain stem glioma is a disease in which benign (noncancer) or malignant (cancer) cells form in the tissues of the brain stem. The brain stem is the part of the brain connected to the spinal cord. It is located in the lowest part of the brain,just above the back of the neck. The brain stem is the part of the brain that controls breathing,heart rate,and nerves and muscles used in ...
Adult Brain Tumors Treatment (PDQ®): Treatment - Patient Information [NCI] - Treatment Options for Spinal Cord Tumors
Treatment of spinal cord tumors may include the following:Surgery to remove the tumor.Radiation therapy.Chemotherapy (systemic and/or intrathecal), if the tumor has spread to the leptomeninges (leptomeningeal carcinomatosis). Radiation therapy may also be given.Supportive care may be given for leptomeningeal carcinomatosis.A clinical trial of a new treatment.
Important It is possible that the main title of the report Medulloblastoma is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. ...
Adult Brain Tumors Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Recurrent Adult Brain Tumors
SurgeryRe-resection of recurrent brain tumors is used in some patients. However, the majority of patients do not qualify because of a deteriorating condition or technically inoperable tumors. The evidence is limited to noncontrolled studies and case series on patients who are healthy enough and have small enough tumors to technically debulk. The impact of reoperation versus patient selection on survival is not known.Localized ChemotherapyCarmustine wafers have been investigated in the setting of recurrent malignant gliomas, but the impact on survival is less clear than at the time of initial diagnosis and resection. In a multicenter randomized, placebo-controlled trial, 222 patients with recurrent malignant primary brain tumors requiring reoperation were randomly assigned to receive implanted carmustine wafers or placebo biodegradable wafers. Approximately half of the patients had received prior systemic chemotherapy. The two treatment groups were well balanced at baseline.
Neuroblastoma Screening (PDQ®): Screening - Patient Information [NCI] - General Information About Neuroblastoma Cancer
Neuroblastoma is a disease in which malignant (cancer) cells form in nerve tissue.Neuroblastoma often begins in the nerve tissue of the adrenal glands. There are two adrenal glands, one on top of each kidney, in the back of the upper abdomen. The adrenal glands make important hormones that help control heart rate, blood pressure, blood sugar, and the way the body reacts to stress. Neuroblastoma may also begin in the abdomen, chest, spinal cord, or in nerve tissue near the spine in the neck.Anatomy of the female urinary system showing the kidneys, adrenal glands, ureters, bladder, and urethra. Urine is made in the renal tubules and collects in the renal pelvis of each kidney. The urine flows from the kidneys through the ureters to the bladder. The urine is stored in the bladder until it leaves the body through the urethra.Neuroblastoma most often begins during early childhood, usually in children younger than 5 years of age.See the PDQ summary on Neuroblastoma Treatment for more
Childhood Ependymoma Treatment (PDQ®): Treatment - Patient Information [NCI] - General Information About Childhood Ependymoma
Childhood ependymoma is a disease in which malignant (cancer) cells form in the tissues of the brain and spinal cord. The brain controls vital functions such as memory and learning,the senses (hearing,sight,smell,taste,and touch),and emotion. The spinal cord is made up of bundles of nerve fibers that connect the brain with nerves in most parts of the body. About 1 in 11 childhood brain ...
Childhood Brain Stem Glioma Treatment (PDQ®): Treatment - Patient Information [NCI] - Treatment Option Overview
There are different types of treatment for children with brain stem glioma. Different types of treatment are available for children with brain stem glioma. Some treatments are standard (the currently used treatment), and some are being tested in clinical trials. A treatment clinical trial is a research study meant to help improve current treatments or obtain information on new treatments for patients with cancer. When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment. Because cancer in children is rare, taking part in a clinical trial should be considered. Some clinical trials are open only to patients who have not started treatment. Children with brain stem glioma should have their treatment planned by a team of health care providers who are experts in treating childhood brain tumors.Treatment will be overseen by a pediatric oncologist, a doctor who specializes in treating children with cancer. The
Neuroblastoma Screening (PDQ®): Screening - Patient Information [NCI] - What is screening?
Screening is looking for cancer before a person has any symptoms. This can help find cancer at an early stage. When abnormal tissue or cancer is found early,it may be easier to treat. By the time symptoms appear,cancer may have begun to spread. Scientists are trying to better understand which people are more likely to get certain types of cancer. They also study the things we do and the ...
Childhood Brain Stem Glioma Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Changes to This Summary (01 / 23 / 2013)
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.Untreated Childhood Brain Stem GliomaAdded Warren et al. as reference 18 and level of evidence 2A.This summary is written and maintained by the PDQ Pediatric Treatment Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.