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Adult Brain Tumors Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Classification of Adult Brain Tumors

WHO Grades of CNS Tumorsa

a Reprinted with permission from Louis, DN, Ohgaki H, Wiestler, OD, Cavenee, WK.World Health Organization Classification of Tumours of the Nervous System. IARC, Lyon, 2007.
Astrocytic tumors
Subependymal giant cell astrocytomaX   
Pilocytic astrocytomaX   
Pilomyxoid astrocytoma X  
Diffuse astrocytoma X  
Pleomorphic xanthoastrocytoma X  
Anaplastic astrocytoma  X 
Glioblastoma   X
Giant cell glioblastoma   X
Gliosarcoma   X
Oligondendroglial tumors
Oligodendroglioma X  
Anaplastic oligodendroglioma  X 
Oligoastrocytic tumors
Oligoastrocytoma X  
Anaplastic oligoastrocytoma  X 
Ependymal tumors
Myxopapillary ependymomaX   
Ependymoma X  
Anaplastic ependymoma  X 
Choroid plexus tumors
Choroid plexus papillomaX   
Atypical choroid plexus papilloma X  
Choroid plexus carcinoma  X 
Other neuroepithelial tumors
Angiocentric gliomaX   
Chordoid glioma of the third ventricle X  
Neuronal and mixed neuronal-glial tumors
Anaplastic ganglioma  X 
Desmoplastic infantile astrocytoma and gangliogliomaX   
Dysembryoplastic neuroepithelial tumorX   
Central neurocytoma X  
Extraventricular neurocytoma X  
Cerebellar liponeurocytoma X  
Paraganglioma of the spinal cordX   
Papillary glioneuronal tumorX   
Rosette-forming glioneural tumor of the fourth ventricleX   
Pineal tumors    
Pineal parenchymal tumor of intermediate differentiation XX 
Pineoblastoma   X
Papillary tumor of the pineal region XX 
Embryonal tumors
Medulloblastoma   X
CNS primitive neuroectodermal tumor (PNET)   X
Atypical teratoid/rhabdoid tumor   X
Tumors of the cranial and paraspinal nerves
Malignant peripheral nerve sheath tumor (MPNST) XXX
Meningeal tumors
Atypical meningioma X  
Anaplastic/malignant meningioma  X 
Hemangiopericytoma X  
Anaplastic hemangiopericytoma  X 
Tumors of the sellar region
Granular cell tumor of the neurohypophysisX   
Spindle cell oncocytoma of the adenohypophysisX   


  1. Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000.
  2. Brain and spinal cord. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 593-7.
  3. Kleihues P, Burger PC, Scheithauer BW: The new WHO classification of brain tumours. Brain Pathol 3 (3): 255-68, 1993.
  4. Louis DN, Ohgaki H, Wiestler OD, et al.: The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114 (2): 97-109, 2007.

WebMD Public Information from the National Cancer Institute

Last Updated: February 25, 2014
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