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Classification of Adult Brain Tumors

    WHO Grades of CNS Tumorsa

    a Reprinted with permission from Louis, DN, Ohgaki H, Wiestler, OD, Cavenee, WK.World Health Organization Classification of Tumours of the Nervous System. IARC, Lyon, 2007.
    Astrocytic tumors
    Subependymal giant cell astrocytomaX   
    Pilocytic astrocytomaX   
    Pilomyxoid astrocytoma X  
    Diffuse astrocytoma X  
    Pleomorphic xanthoastrocytoma X  
    Anaplastic astrocytoma  X 
    Glioblastoma   X
    Giant cell glioblastoma   X
    Gliosarcoma   X
    Oligondendroglial tumors
    Oligodendroglioma X  
    Anaplastic oligodendroglioma  X 
    Oligoastrocytic tumors
    Oligoastrocytoma X  
    Anaplastic oligoastrocytoma  X 
    Ependymal tumors
    Myxopapillary ependymomaX   
    Ependymoma X  
    Anaplastic ependymoma  X 
    Choroid plexus tumors
    Choroid plexus papillomaX   
    Atypical choroid plexus papilloma X  
    Choroid plexus carcinoma  X 
    Other neuroepithelial tumors
    Angiocentric gliomaX   
    Chordoid glioma of the third ventricle X  
    Neuronal and mixed neuronal-glial tumors
    Anaplastic ganglioma  X 
    Desmoplastic infantile astrocytoma and gangliogliomaX   
    Dysembryoplastic neuroepithelial tumorX   
    Central neurocytoma X  
    Extraventricular neurocytoma X  
    Cerebellar liponeurocytoma X  
    Paraganglioma of the spinal cordX   
    Papillary glioneuronal tumorX   
    Rosette-forming glioneural tumor of the fourth ventricleX   
    Pineal tumors    
    Pineal parenchymal tumor of intermediate differentiation XX 
    Pineoblastoma   X
    Papillary tumor of the pineal region XX 
    Embryonal tumors
    Medulloblastoma   X
    CNS primitive neuroectodermal tumor (PNET)   X
    Atypical teratoid/rhabdoid tumor   X
    Tumors of the cranial and paraspinal nerves
    Malignant peripheral nerve sheath tumor (MPNST) XXX
    Meningeal tumors
    Atypical meningioma X  
    Anaplastic/malignant meningioma  X 
    Hemangiopericytoma X  
    Anaplastic hemangiopericytoma  X 
    Tumors of the sellar region
    Granular cell tumor of the neurohypophysisX   
    Spindle cell oncocytoma of the adenohypophysisX   


    1. Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000.
    2. Brain and spinal cord. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 593-7.
    3. Kleihues P, Burger PC, Scheithauer BW: The new WHO classification of brain tumours. Brain Pathol 3 (3): 255-68, 1993.
    4. Louis DN, Ohgaki H, Wiestler OD, et al.: The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114 (2): 97-109, 2007.

    This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

    WebMD Public Information from the National Cancer Institute

    Last Updated: February 25, 2014
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